Posted on

minimum concentrations of topical cbd oil

We offer real benefits to our authors, including fast-track processing of papers.

106. Ramezani V, Honarvar M, Seyedabadi M, Karimollah A, Ranjbar AM, Hashemi M. Formulation and optimization of transfersome containing minoxidil and caffeine. J Drug Deliv Sci Technol. 2018;44:129–135. doi:10.1016/j.jddst.2017.12.003

Open Access

148. Katsuyama S, Mizoguchi H, Kuwahata H, et al. Involvement of peripheral cannabinoid and opioid receptors in β‐caryophyllene‐induced antinociception. European j Pain. 2013;17(5):664–675. doi:10.1002/j.1532-2149.2012.00242.x

84. Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: a dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639–641.

103. Kim -S-S, Baik JS, Oh T-H, Yoon W-J, Lee NH, Hyun C-G. Biological activities of Korean citrus obovoides and citrus natsudaidai essential oils against acne-inducing bacteria. Biosci Biotechnol Biochem. 2008;72(10):2507–2513. doi:10.1271/bbb.70388

a Active-controlled trial, amisulpride. b Concomitant treatment. c CBD-rich botanical extracts capsules contained other compound (up to 4.7% THC). IR: individually randomized; NR: non-randomized; CR: cluster randomized; CBD: cannabidiol; HDL: high-density lipoprotein.

Although this review followed the recommendations for rigorous systematic reviews, it bears limitations here amongst a language and date restriction applied as well as a search strategy limited to electronic databases. However unlikely, other studies may not have been identified which can limit the applicability of the findings. Most of the disorders/diseases were only evaluated in single studies providing limited experience and no option to pool data, and some studies failed to present specific inclusion criteria meaning no restriction as to study group. The studies identified that evaluated identical conditions, regrettably employed different endpoints or tools of assessment.

Study selection and characteristics

The methodological quality of randomized controlled trials (RCTs) was assessed using the Cochrane risk of bias tool [15]. If all domains were judged as being at low risk of bias, the study was considered at low risk of bias. If at least one domain was rated high, the study was considered at high risk of bias. In situations that differ from those described above, the study was considered at unclear rick of bias. Data extraction and risk of bias was assessed by two independent reviewers and disagreements were solved by a third reviewer or with consensus.

No effect was reported in the studies included in this review for the treatment of Crohn’s disease, ulcerative colitis and type 2 diabetes with doses ranging between 20 and 250 mg/day for a treatment duration of 8 – 13 weeks [38-40]. While positive results were reported on seizure improvement with doses ranging from 350 to 2,000 mg/day and on the quality of life for patients with ADRs following HPV vaccine, with doses ranging from 25 to 150 mg/day, after 12 weeks of treatment [31, 33]. No definitive conclusion can be made on doses required for a positive effect since this may depend on the outcome assessed and study population.

A label single arm trial [38] assessed long-term use of isolated CBD (5 mg/kg/day incremental doses in some patients reaching 2,000 mg/day) as an adjunct to anti-epileptic drugs, in patients refractory to conventional anti-seizure drugs and reported a decrease in seizure frequency (144.4 to 52.2, P = 0.01) and severity measured with the Chalfont seizure severity scale (from 80.7 at baseline to 39.2, P < 0.0001) at week 12, with values being stable thereafter (total follow-up 48 weeks). The other two studies [39, 40] included reported on the chronic administration effect of CBD in the form of a topical cream for skin disorders and sublingual oil drops (25 mg/day up to 150 mg/day for 12 weeks) for adverse drugs reaction (ADR) following human papilloma virus (HPV) vaccine, with a 3-month follow-up period each. The topical application produced positive results for serous skin inflammatory conditions such a psoriasis, acne and related scars, with no side effects being reported [39]. The sublingual administration of CBD also improved the quality of life in girls presenting with ADR following HPV vaccine when added to standard treatment. The evidence however arises from two case series and this should be taken into consideration when considering the results from this study [40].