Numerous animal models have shown that CBD may yield great psychiatric potential, offering anti-anxiety and antidepressant-like properties. The effect of CBD on serotonin 1A receptors may influence be key.
“There is scientific evidence to suggest that CBD has antidepressant-like effects,” Rosalia Yoon, Ph.D., a Research Scientist for Apollo Cannabis Clinics in Ontario, Canada, told Weedmaps. “From a neurophysiological perspective, the endocannabinoid system (ECS) is known to modulate functions associated with cognition, mood, sleep, pain, reward, and motivation; and decreased ECS activity has been postulated to account for some of the symptomatology associated with depression, such as low mood, anhedonia, anxiety, and decreased pain tolerance.”
“For example, one middle-aged man who found the side effects of antidepressants to be intolerable, experiencing insomnia and decreased sexual function, started using low doses of a 4:1 CBD:THC tincture. He self-reported a 90% improvement of his depression symptoms with no side effects,” she said.
There is scientific evidence to suggest that CBD has antidepressant-like effects. Photo by: Gina Coleman/Weedmaps
While studies are limited, “Most of the evidence on the mood regulatory effects of CBD comes from pre-clinical studies. CBD has been demonstrated to exert dose-dependent antidepressant-like effects in animal models of depression in various rodent species,” Yoon explained. “Of note, CBD appears to exert acute antidepressant effects, suggesting that it may confer temporal advantages over standard antidepressant medications, for which the onset of action typically occurs 6-8 weeks after initiation of treatment. Further, research has shown that a single dose of CBD has effects lasting up to one week in rodents, suggesting sustained antidepressant effects.”
Interest in the potential mental health uses of cannabidiol (CBD) has grown tremendously in recent years, including the use of CBD for depression. CBD is a chemical compound found in the Cannabis sativa plant, also known as marijuana or hemp.
CBD, on the other hand, is purported to have a wide range of health benefits without these psychoactive effects. Some research suggests that CBD has antidepressant-like effects, which means it may hold promise in alleviating symptoms of depression.
Despite claims about CBD’s purported mental health benefits, it is important to understand that the research on its use is still limited. There have been studies done, but many of these have limitations and further research is needed in order to fully understand CBD’s therapeutic potential.
CBD holds promise, but that does not mean that you should turn to cannabidiol products over traditional treatments for depression.
It is also important to note that CBD is available in isolate (only CBD), broad-spectrum (contains other cannabinoids but not THC), and full-spectrum (contains other cannabinoids, including THC).