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At a minimum, the evidence at this point suggests that grapefruit warnings on medications should also apply to CBD. And it’s important to check with your doctor before taking CBD, especially if you’re taking other medications.

You’re probably familiar with “grapefruit warnings” that appear on a variety of medications, or maybe your doctor or pharmacist has told you to avoid grapefruit or grapefruit juice when taking a particular med.

What’s the risk?

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Apart from a short list of possible side-effects, bigger concerns revolve around how CBD interacts with other drugs. Here’s a brief breakdown of possible risks if you’re thinking of trying it out.

Interest in cannabidiol (CBD) is exploding. Now that major retailers are carrying CBD products, plus an enormous selection online, curiosity is only going up. But we also need some healthy skepticism and caution to balance out the exuberance. CBD research is still in the early stages, and marketing is predictably outpacing facts. Concerns about safety, among other topics, are getting lost in the hype.

CBD is similar to grapefruit in that it also binds with those enzymes, but research suggests that it’s possibly even more potent because it binds in multiple parts of the gut and liver (grapefruit mainly affects enzymes within the small intestine). Once an enzyme has been inhibited, the effect isn’t immediately reversed. It can take days for enzyme function to return to baseline and start the process again.

What’s the best path forward?