Another way to help assure a particular CBD oil’s quality is by finding a product that was manufactured in a Current Good Manufacturing Practice (CGMP)-compliant facility, which must follow certain FDA standards to qualify.
Consumers looking to reap the potential benefits of cannabidiol (CBD), the wildly popular non-intoxicating cannabinoid found in the cannabis plant, will likely run into not only CBD oil, but also many different types of CBD cream and other topical CBD products.
When topicals are applied to the skin, they can potentially benefit not only the surface of the skin, but also below. When CBD is applied topically to the skin, it penetrates both the dermal and subdermal layers of the skin.
Chasen said when it comes to picking the best CBD topical or cream for aches and pains or skin problems, research is essential.
Finding the most effective mixing ingredients that will properly mingle with CBD oil or CBD isolate is also important. A carrier oil, such as coconut oil, shea butter, CBD tincture, or isolate can also be mixed to create a therapeutic homemade topical.
CBD-infused topicals include lotions, salves, creams, or transdermal patches that are applied on the skin for relief on the surface or even deeper in muscle tissue. Photo by: Gina Coleman/Weedmaps
“Much of the scientific evidence points to CBD’s ability to modulate pain, inflammation, and the histamine response when applied topically,” Chasen said. “It has been shown to diminish redness, help with painful arthritic joints, and quicken the healing process.”
Finally, you have receptors called TrpV1 that detect and regulate your body temperature. When activated, they put out heat, soothing your pain receptors. Using this channel, CBD makes these pain receptors hyperactive for a period of time, causing them to get hot, desensitizing them and downregulating those pain-sensing nerve endings.
There is an argument to be made for the simple fact that science hasn't caught up to the trend (and laws) of cannabis yet. (Here's what research has to say about the potential benefits of CBD and cannabis so far.) And there are doubtlessly researchers testing the efficacy of CBD creams for pain relief as we speak.
This brings up an underlying issue with all CBD and hemp products: There is no regulation around how much active CBD or THC is in each cream or how much of the compound is needed to see relief. Read: "If you have three products that say 1 percent CBD infused in coconut oil, one could be great and the other two could be crap—that's the reality of cannabis medicine right now," says Gerdeman. (See: How to Buy Safe and Effective CBD Products)
How CBD and Cannabis Might Help Pain Relief
The fatty tissue can only hold so much oil, so, theoretically, if you apply enough of a cannabis cream to your skin, it might leak down into your skeletal muscle just out of diffusion, adds Sexton. But there's no study to show this, and that means you're going to be rubbing on a whole lot of the stuff.
A study analysis in the Journal of Pain Research confirms that topical use of certain cannabinoid topicals can reduce pain in animals with inflammation or neuropathic pain. And science has found topical creams with THC and CBD help relieve pain for conditions like multiple sclerosis. But for the vast majority of chronic pain — and most certainly for acute pain like post-workout — the scientific jury is 100 percent still out. "There's a little bit of data in support of CBD for pain relief, but to go from animal to human is a giant leap," says Sexton.
Science has shown that cannabis is an effective pain reliever, reinforced in a massive new report from the National Academies of Sciences, Engineering, and Medicine. But there's a big difference between ingesting cannabis or its individual chemicals orally and absorbing it topically through your skin.
If you read the ingredient list, often everything in the jar is straight from mother earth. As long as that's indeed the case with the cannabis cream you have your eye on, the formula is immensely safe, chemically, says Gregory Gerdeman, Ph.D., neurophysiologist who researches cannabinoid biology and pharmacology at Eckerd College in Saint Petersburg, FL. And since hemp pain relief creams are formulated to be topical (absorbing into the top layer of skin) and not transdermal (which would pass through the skin and into your bloodstream) there's no risk of getting high, explains Gerdeman. (P.S. Here's How Marijuana Affects Athletic Performance.)
Sidestepping the CB1 and CB2 receptors means that CBD can mute pain without the high sensation delivered by THC. Not only does CBD have very little interest in switching on CB1, cannabidiol can actually mute any signals sent to that receptor. Researchers looking for safer pain treatments want to take advantage of this action because it means that CBD won’t spark addiction.
Pain is a big driver behind opioid addiction. Many people who began treating chronic pain with prescription opioids have switched to heroin when other drugs became difficult to get. A lot of people have died as a result, says Yasmin Hurd , an addiction specialist at the Icahn School of Medicine at Mount Sinai in New York. “We have so many people in our society now experimenting with CBD to manage pain,” she says. “They are going to their clinicians and asking them for CBD.”
Hurd suggests telling your doctor if you are using CBD creams because what’s absorbed into your skin will get into your bloodstream. “These are sometimes things people don’t appreciate when they are putting cream ‘only on my knee,’” says Hurd. “We also have a lot of seniors using CBD creams for arthritic pain and we need to know sooner rather than later whether this chemical cream used by so many people can indeed be effective.”
Consumers aren’t waiting for clinical trials. But they need to remember, says Hurd, that slathering on creams can be risky, considering how the skin absorbs everything. Even topical CBD can react with oral medications.
By the time you feel any annoying itch or prick of pain, CB1 and CB2 receptors on your skin cells have already fired off signals to help dampen those unpleasant vibes. These receptors — part of the body’s endocannabinoid system — spend their workdays responding to chemical messages that help our skin nurture a healthy balance. CBD cream bypasses the CB1 and CB2 receptors and heads straight for a neurotransmitter middleman that blocks signals for pain and itch by working through agents called anandamide and 2-AG.
Opioid pain relief can cause nausea, constipation and addiction. Standard anti-inflammatory meds carry the risk of stomach issues, including bleeding. The limited options prompt many folks to try creams and lotions containing cannabidiol (CBD).
Researchers have confirmed that CBD works against pain and inflammation , and they’re still finding new ways that it works in the body . They're also working to nail down the proper dose of topical CBD needed for pain relief. For example, the dose that brings relief to achy joints may be insufficient to effectively treat nerve damage in feet. While rubbing topical CBD onto the skin seems to work, researchers still need to figure out how much skin coverage is most effective. Some skin creams also contain menthols, which carry their own pain relief and anti-inflammatory properties, possibly masking any effect from the CBD itself.