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epidiolex isolated cbd

Many people consider the ‘best of both worlds’ option to be broad spectrum CBD. Broad spectrum takes full spectrum and chemically renders out all of the THC. This produces a product still rich in phytocannabinoids but removed of all THC. Which makes it a great product for kids and seniors.

Today, we know that all of the compounds in cannabis work together to create a synergistic effect. When GW Pharmaceuticals did clinical trials of pure CBD and pure tetrahydrocannabinol, the trial participants went through weird and potentially harmful side effects. If tetrahydrocannabinol is illegal in your area, you may not be able to use a whole-plant product. Thankfully, innovators like Tweedle Farms in Colorado are working to develop hemp plants for CBD that do not contain any tetrahydrocannabinol. If you want to treat a medical ailment, using the whole plant is a better option than just using an extract.

Once you understand the difference between an isolate and full-spectrum CBD, the next step is determining which option you want to buy. An isolate is the purest form of CBD and does not have any psychoactive effects. Since it is odorless and tasteless, it is ideal for cooking and eating. The main problem with isolates is that you will not get to take advantage of the entourage effect because there are no other cannabinoids present in the final product.

What Is the Entourage Effect?

CBD-only medications became popular after Charlotte’s Web was found to help with epilepsy in children. Many CBD medications no longer use the whole plant like Charlotte’s Web does. Instead, these medications use pure CBD. Since other compounds in the cannabinoid spectrum may have a synergistic effect, many patients could be missing out on potential benefits by using CBD-only medicines.

The entourage effect can maximize the therapeutic benefits of CBD oil. Each cannabis plant has hundreds of different chemicals. Out of all of these chemicals, there are about 100 compounds that are cannabinoids. Other compounds like flavonoids and terpenes can also be found within the plant. Together, these chemicals can alter or increase some of marijuana’s effects.

An estimated 40 percent of people will experience toxic psychosis if they take 10 milligrams of tetrahydrocannabinol in one dose. Scientists believe that CBD can mitigate marijuana’s paranoia effects and toxic psychosis. Companies like GW Pharmaceuticals create products that contain both tetrahydrocannabinol and CBD to avoid these side effects. Recently, GW Pharmaceuticals made Sativex in order to treat multiple sclerosis. To avoid effects like psychosis, Sativex is made out of equal parts of tetrahydrocannabinol and CBD.

Other than working with cannabinoids, CBD could also work with terpenes in the plant. Terpenoids are remarkable substances that give cannabis and other plants their aroma and flavor. For example, pinene has a pine-like scent. In comparison, limonene smells like lemon or citrus fruits.

But Epidiolex is not a one-size-fits-all treatment, and some patients have reported adverse effects. A 2015 study of single compound vs. whole-plant CBD could provide some insight as to why Epidiolex can be problematic. Epidiolex is made from isolated, single-molecule CBD, while CBD oils are made of whole plant cannabinoids. Researchers found that the whole plant model is more effective than single-molecule CBD.

However, Epidiolex is just one potential cannabis-based treatment for epilepsy, and other studies have examined how whole-plant cannabidiol (CBD) oil may work better as the treatment does not trigger side effects that some patients have experienced with Epidiolex, such as diarrhea.

The Studies

Several key studies led to federal approval of Epidiolex as a legal, obtainable treatment option for people suffering from severe forms of epilepsy including Dravet syndrome and Lennox-Gastaut syndrome, both of which cause frequent and dramatic seizures in children.

For other patients, Epidiolex has been the answer. Molly Hendershot has suffered from epileptic seizures since she was four months old, according to her mother, Allison, who was interviewed on CBS News in 2018. Now 13, Molly swallows Epidiolex in the palatable form of a strawberry-flavored syrup to manage her seizures. Before Epidiolex, the Rochester, New York -based family was considering relocation to Colorado to have legal access to marijuana.

Cannabinoids in the treatment of epilepsy: Hard evidence at last?” is a 2017 study published in the Journal of Epilepsy Research that answered the question with optimistic findings. Researchers found that patients with Dravet and Lennox-Gastaut syndromes responded well to CBD treatment with a decrease in epileptic seizures observed in significantly more patients in the control groups than in the placebo groups.

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It is not known if EPIDIOLEX is safe and effective in children under 1 year of age.


Please refer to the EPIDIOLEX Medication Guide and Instructions for Use for additional important information.

EPIDIOLEX may affect the way other medicines work, and other medicines may affect how EPIDIOLEX works. Do not start or stop other medicines without talking to your healthcare provider. Tell healthcare providers about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and cannabis-based products.

What Additional Information Applies to Women?