CBD stands for cannabidiol. It is the second most prevalent of the active ingredients of cannabis (marijuana). While CBD is an essential component of medical marijuana, it is derived directly from the hemp plant, which is a cousin of the marijuana plant. While CBD is a component of marijuana (one of hundreds), by itself it does not cause a "high." According to a report from the World Health Organization, "In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health related problems associated with the use of pure CBD."
CBD is readily obtainable in most parts of the United States, though its exact legal status is in flux. All 50 states have laws legalizing CBD with varying degrees of restriction, and while the federal government still considers CBD in the same class as marijuana, it doesn’t habitually enforce against it. In December 2015, the FDA eased the regulatory requirements to allow researchers to conduct CBD trials. Currently, many people obtain CBD online without a medical cannabis license. The government’s position on CBD is confusing, and depends in part on whether the CBD comes from hemp or marijuana. The legality of CBD is expected to change, as there is currently bipartisan consensus in Congress to make the hemp crop legal which would, for all intents and purposes, make CBD difficult to prohibit.
How is cannabidiol different from marijuana?
Cannabidiol (CBD) has been recently covered in the media, and you may have even seen it as an add-in booster to your post-workout smoothie or morning coffee. What exactly is CBD? Why is it suddenly so popular?
Some CBD manufacturers have come under government scrutiny for wild, indefensible claims, such that CBD is a cure-all for cancer, which it is not. We need more research but CBD may be prove to be an option for managing anxiety, insomnia, and chronic pain. Without sufficient high-quality evidence in human studies we can’t pinpoint effective doses, and because CBD is currently is mostly available as an unregulated supplement, it’s difficult to know exactly what you are getting. If you decide to try CBD, talk with your doctor — if for no other reason than to make sure it won’t affect other medications you are taking.
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This means topical preparations of cannabis do not cause intoxication, even if they contain THC. Because of this, they may be suitable for a much broader demographic than inhaled or oral preparations containing this high-inducing cannabinoid.
Still, there are a few preliminary studies, which have no doubt spawned some of these marketing campaigns. For example, in 2014, one study evidenced that CBD’s lipostatic, antiproliferative, and anti-inflammatory effects could benefit those with acne vulgaris. This early research now seems to have led to an observational clinical trial on the condition, sponsored by the CBD brand Charlotte’s Web.
Whether applied through a topical/transdermal application or more popular administration routes like inhaled and oral formulas, the human body interacts with cannabinoids via the endocannabinoid system. This system regulates many biological processes through a network of receptors and chemical neurotransmitters, such as pain, inflammation, mood, memory, and more.
Research into Topical Cannabis and Cannabinoids Limited
Consumers and researchers alike are intrigued by the possible medicinal benefits of topically applied cannabinoids, like tetrahydrocannabinol (THC) and cannabidiol (CBD). There is so much excitement, in fact, some analysts predict the cannabis topicals market will outpace the growth of the cannabis sector as a whole.
But patients and consumers are not waiting for the results of clinical trials. Cannabinoids are already making their way into skincare lines and sports medicine. But beyond the over-the-counter market, what does the current body of study tell us about its true medicinal potential? Is there a viable future for cannabis within topical plant-based medicines?
Another interesting study used CBD ointment for inflammatory skin diseases and cutaneous scars. This study, completed in 2019, worked with 20 patients experiencing psoriasis and dermatitis.
Due to its more favorable legal status, CBD is a primary target for cannabis-based topicals products and already prolific in products like cosmetics, anti-aging creams, and other wellness-style items. However, the research is playing a game of catch-up to the many benefits these products claim to provide.
Results: The study population included 62.1% males and 37.9% females with a mean age of 68 years. There was a statistically significant reduction in intense pain, sharp pain, cold and itchy sensations in the CBD group when compared to the placebo group. No adverse events were reported in this study.
Conclusion: Our findings demonstrate that the transdermal application of CBD oil can achieve significant improvement in pain and other disturbing sensations in patients with peripheral neuropathy. The treatment product was well tolerated and may provide a more effective alternative compared to other current therapies in the treatment of peripheral neuropathy.
Background: Peripheral neuropathy can significantly impact the quality of life for those who are affected, as therapies from the current treatment algorithm often fail to deliver adequate symptom relief. There has, however, been an increasing body of evidence for the use of cannabinoids in the treatment of chronic, noncancer pain. The efficacy of a topically delivered cannabidiol (CBD) oil in the management of neuropathic pain was examined in this four-week, randomized and placebocontrolled trial.
Methods: In total, 29 patients with symptomatic peripheral neuropathy were recruited and enrolled. 15 patients were randomized to the CBD group with the treatment product containing 250 mg CBD/3 fl. oz, and 14 patients were randomized to the placebo group. After four weeks, the placebo group was allowed to crossover into the treatment group. The Neuropathic Pain Scale (NPS) was administered biweekly to assess the mean change from baseline to the end of the treatment period.
Keywords: CBD; cannabis sativa; diabetic neuropathy; hemp; nerve pain; review..