Marijuana and nicotine in cigarettes will not interfere with the doxycycline. However if you want to give your body the best chance possible to recover from the infection you are probably best to avoid both until you have recovered.
Medically reviewed by Drugs.com. Last updated on Oct 27, 2020.
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For instance, the CBD based drug, EPIDIOLEX® approved in the United States for seizures associated with Lennox‐Gastaut and Dravet syndromes, is increasingly either being used as a supplementary treatment, or even replacing the traditionally used anti-epileptic drugs clobazam, and valproate, as well as stiripentol, topiramate, rufinamide, and N‐desmethylclobazam respectively.
There are also other medications known as “prodrugs” that first need to be metabolized into its therapeutic compounds as opposed to being a therapeutic compound in and of itself (like most medications). In other words, the inactive compound is ingested, and once in the body, it is processed into its active compound.
Let’s find out why.
CBD and anti-epileptic drugs
As mentioned, and contrary to popular belief and anecdotal evidence, CBD is not a biologically inert compound. Rather, CBD has a complex pharmacokinetic and pharmacodynamic profile similar to any other medication, and has the potential to interact with other medications and medical conditions.
This, along with the rise in the popularity of the medical and complimentary use of CBD, researchers are also starting to investigate drug interactions with CBD more directly.
In yet another such study, but with researchers this time looking into the clinical implications and importance of DDIs between anticancer agents and CBD in patients with cancer, the reviewers found that there was limited information available, with most of the data coming from in vitro studies and that the true in vivo implications are not well-known. This lead them to believe that erring on the side of caution is the best option, and that doctors and pharmacists should always consider the possibility of interactions and their consequences whenever they are aware of a patient using CBD products.
Despite these ADEs, the researchers concluded that the effective dose of 750 mg of cannabidiol (approximately 20 mg/kg/day for a 75‐kg adult), was mostly well tolerated when co-administered with clobazam, stiripentol, or valproate and that ADEs only occurred in patients for which there was no dosage titration.
Antibiotics are prescribed by the millions across America every year to combat a wide range of bacterial infections. A form of antimicrobial drug, antibiotics are used to either treat or prevent further bacterial infections from occurring.
CBD has actually been shown to inhibit the Cytochrome P-450 system, which can alter the way the system metabolizes certain other drugs that pass through – in this case, antibiotics. In other words, there is a chance that those consuming antibiotics and CBD at the same time could be at risk of taking less or more antibiotics than required, which could be dangerous and even lead to an overdose.
What Are Antibiotics?
We have seen dozens of cases where patients have been able to reduce their prescription meds or even stop taking them altogether as a result of the actions of CBD, but having this core understanding of the way CBD interacts with different drugs is vital in avoiding any unpleasant or dangerous side effects!
Among the many different drugs that can have an impact on the Cytochrome system are antibiotics, steroids, anesthetics, antidepressants , beta-blockers, and many more! But what exactly does this mean for CBD users?
This should be a rule of thumb with any medication that is affected by cannabidiol, so we can’t stress enough the importance of checking with a doctor before adding CBD to your list of treatments.