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do eliquis and cbd topicals interact

More research is needed to determine if there is a specific dose at which CBD begins to inhibit cytochrome 450. You should speak with a health care provider to establish the amount of CBD, if any, that is safe to take.

Like grapefruit and grapefruit juice, CBD can affect how some medications are metabolized. If your doctor or pharmacist has said to avoid grapefruit or grapefruit juice with your medication, this may be a good time to ask if oral CBD oil may also interact with your medication.

CBD and anti-seizure medication

One small study suggests that this interaction could help relieve pain and reduce opioid use when used together. 4 However, more research should be done on this topic.

Opioids, such as hydrocodone/acetaminophen (Vicodin, Norco), oxycodone, (Oxycontin, Percocet) and fentanyl (Duragesic) are a powerful class of drugs used to treat pain that can be addictive. Research suggests that there is a relationship between the body’s opioids—endogenous, or naturally occurring opioids—and endocannabinoid system, although the exact mechanisms remain unknown.

According to one study, people who take anti-epileptic medication for refractory epilepsy, such as clobazam (Onfi, Sympazan), may benefit from taking CBD. 2 This is because both drugs are metabolized in cytochrome P450 and may enhance the medication’s effects. Dose adjustments of clobazam may be necessary and this combination should be strictly monitored by a health care professional.

Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.

Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.

CBD can alter the effects of other drugs

Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included

Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.

The researchers further warned that while the list may be used as a starting point to identify potential drug interactions with marijuana or CBD oil, plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned), and may contain many other compounds that can increase the risk of unintended drug interactions.