Cannabidiol[CBD] is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, and anti-inflammatory and neuroprotective properties. It is a major phyto-cannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical implications are currently being investigated, CBD has shown promise as a therapeutic and pharmaceutical drug target. In particular, CBD has shown promise as an analgesic, anticonvulsant, muscle relaxant, anxiolytic, antipsychotic and has shown neuroprotective, anti-inflammatory, and antioxidant activity, among other currently investigated uses [1, 2] .
Cannabidiol was isolated from marijuana in the late 1930s, but only in the 1963 were its structure and stereochemistry first elucidated  . Early studies focusing on CBD pharmacology started in the 1970s, with the first relevant finding concerning its hypnotic and anticonvulsant properties, published in 1981  . Since then, a large body of pharmacological effects has been demonstrated, both in preclinical and in clinical studies.
EPA SARA (Superfund Amendments and Reauthorization Act of 1986) Lists
Conditions to Avoid:Moisture. Protect from light and heat
Work/Hygiene Practice:Normal work and hygiene practices for handling non-hazardous liquid material.
Skin:Wash with soap and water – get medical attention if irritation persists.
Extinguishing Media:Dry Chemical, Carbon Dioxide, Fog, Foam
Other:Slip proof shoes may be worn where spills may occur.
Solubility in Water:Insoluble
Let’s go back to the 10,000 kg of CBD isolate per month PO. This equals 120,000 kg of isolate a year. Current estimates suggest there are around 26,000 acres dedicated to hemp production in the US . Therefore, the entire production of CBD isolate in the US, assuming every single acre is dedicated to CBD-rich cultivars, could yield around 1.4 million kg.
Let’s start by trying to establish how many hemp plants (or how much biomass) can be cultivated per surface area. Canadian provinces like Alberta and Manitoba have very compressive programmes for cultivation of industrial hemp. The websites of both programmes offer very detailed numbers of expected yields depending of the crop modality (fiber, seed or mixed) [2, 3]). Unfortunately, none of these numbers really apply to current practices in outdoor hemp operations specifically seeded for production of CBD-rich cultivars.
I am not a farmer. I have never been in a hemp field but I am a plant physiologist and I like to work around Fermi Problems  for fun. I don’t want to prove or disprove any particular figure or rule of thumb, I just want to share with the network a simple exercise hoping to start a conversation. I welcome all comments and corrections from anyone with first hand experience, expertise or reliable sources.
I was recently on the East Coast visiting a couple of potential sites for my new company. During my visit I had the opportunity to talk with several investors and entrepreneurs looking to move away from the cultivation space into offering post-harvest processes under the “As-A-Service” model.
It is difficult to believe how much disinformation, malarkey and plain old Androgenic Bovine Manure (aka Bullshit) we still have around simple facts and figures when it comes to parametrize outdoor cultivation of hemp and potential production of CBD oils and isolates.
Since plants growing in legal outdoor operations are treated as small trees in an orchard (i.e., they are properly irrigated and fertilized), a plant density of 1 plant per m2 could be used as a reference (this density has been reported for well-cared Cannabis plants growing outdoors [4,5]. At this density well-cared plants can develop large, multi-branched canopies. Using this density, we should expect 4,046 plants per acre. Well-cared Cannabis plants grown outdoors at this density regularly yield 1 to 2 pounds (0.5 – 1kg) of fresh bud per plant [4, 5]. These numbers bring us to a total yield of 2,023 to 4,046 kg of bud per acre. For simplicity let’s settled for 3,000 kg per acre .
Now, before extraction and purification of this biomass could occur the biomass needs to be dried. The Bureau voor Medicinale Cannabis in the Netherlands suggest that saleable material represents about 30 per cent of dried plant weight and about 8 per cent-10 per cent of wet plant weight . As the biomass will not be stored we could assume 80% loss by drying instead of the after mentioned 90%. Hence, we are now down to 600 kg per acre of dry bud ready for extraction. Assuming a 10% CBD content (10% could be seen as an unrealistic high average for wet material but seems to be a good reference for dry material ) we now have 60 kg of CBD available per acre. With a wet dream efficiency of 90% for the extraction and purification process you end with 54 kg of pure CBD isolate per acre.