Buy award winning CBD online. A complete range of CBD (Cannabidiol) oil, CBD skincare and CBD tablets U Love U with ULU. Last month, a U.S. Food and Drug Administration advisory panel unanimously recommended approval of the CBD medication Epidiolex to treat two rare forms of childhood epilepsy. Everyone is talking about CBD Oil. But what is it? Where does it come from? Find out more about this versatile medicine.
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ULU is an award winning CBD company created to help ‘U love U!‘ Our online range of high-quality, premium CBD products is designed in our German and USA laboratories to soak up the stress of life and to support your positive wellbeing. Our ground breaking partnership with The Harley Street Hospital will extend and progress the knowledge and utilisation of CBD across the world.
Hemp CBD Oil
Paul Hembery, the founder of ULU, has been a prominent figure in one of the most high-pressure environments in the world: the very top level of global motorsport formula one.
“I saw people under immense stress, travelling all the time, making very important decisions under huge pressure, and not even able to sleep” says Paul. “So I thought to myself: what can I do to help?”
Paul, embarked on a lengthy programme of research to find healthy alternatives to the traditional stress-busting props of alcohol or tobacco. After spending time in California and seeing the benefits of CBD firsthand, he knew he needed to set up a CBD company to support people looking for real alternatives to classical pharmaceutical solutions – ULU U Love U was the answer. It was also clear that the CBD market was surrounded with a lot of poor information and products. So we partnered with the prestigious Harley Street Hospital in London to bring some integrity and credibility to our mission. We will work hard to progress the knowledge and understanding of this wonderful plant , so that people have a plant based solution to support their lives.
what is CBD?
CBD is the acronym for cannabidiol, which is one of the many naturally-occurring cannabinoids found in the hemp plant. It’s loaded with all sorts of beneficial properties and can be used to support a healthy lifestyle.
CBD is non-psychoactive, so it does not make you feel high when you consume it, unlike the THC cannabinoid (the chemical in marijuana that causes a high.) It is a safe and non-addictive substance and is among the several “phytocannabinoids,” found in the hemp plant. Of the “phytocannabinoids,” CBD is present in the highest concentration in the plant.
CBD is able to have so many support benefits due to its interaction with the Endocannabinoid System (ECS.) The ECS is a complex cell-signalling system found naturally within our bodies. It’s responsible for maintaining homeostasis and regulating things like mood, memory, sleep, pain and even the immune system. CBD effectively boosts the ECS, helping it to function properly, maintaining wellness and balance.
The is no one-size-fits-all formula for getting started with CBD consumption. The method you should use depends on your lifestyle and the health benefits you’re looking to receive. The most important thing is to find a method that works for you!
Understand the methods of CBD consumption, and figure out the one that suits you the best for getting started:
Holding Under Tongue
CBD tinctures and CBD oils are taken by using a dropper to drop the liquid under your tongue and holding it for 30 seconds before swallowing. This is also one of the most popular ways to consume CBD. This method allows you to measure the precise dose with a dropper you want to take. However, there is a slight grassy taste to CBD, which comes through more with this method.
You can also vape CBD (in the e-liquid form) with the help of a CBD vape pen or an e-cigarette. CBD vape oils come in a variety of enjoyable flavours and are absorbed quickly and directly into the body. Simply load the vape oil into a compatible vaping device, inhale and enjoy!
A CBD tablet capsule is the easiest way to consume CBD. You simply need to swallow it. Since it contains a pre-measured dose, you do not have to worry about the measurements. You can also carry the capsules anywhere you go and consume at your convenience.
We also offer a variety of CBD skincare products here at ULU.. Simply apply to clean, dry skin and rub in a circular motion until the CBD becomes absorbed!
We’re a USA CBD company using only pure organic CBD oil sourced from the USA. We’re bringing you a range of pure cbd oil and tablet products, which can change your daily life for the better. And we’re always around if you want to know more. We’d love to hear from you, in person or via our social channels.
Let’s get one thing straight. CBD is not cannabis. Instead, it’s an extract of the hemp plant. We use only the purest extract, free of pesticides and other nasty things.
There’s been a lot of guff talked about CBD. We give you all the facts so that you can see the truth rather than the myths. On this website you’ll find a load of information, both scientific and common sense, helping you to understand fully what CBD is all about. You can talk to us or visit us at any time, as we have a philosophy of complete transparency in everything we do.
We put quality first. There are plenty of CBD products out there (more every day, it seems) but our mission is simple: to provide the very best. Our products are the result of careful research – and we’re confident they will be better than anything else you’ve tried before. We only offer premium CBD products for people who never compromise on quality.
CBD Oil: All the Rage, But Is It Safe & Effective?
MONDAY, May 7, 2018 (HealthDay News) — Cannabidiol (CBD) oil has become the hot new product in states that have legalized medical marijuana.
The non-intoxicating marijuana extract is being credited with helping treat a host of medical problems — everything from epileptic seizures to anxiety to inflammation to sleeplessness.
But experts say the evidence is scant for most of these touted benefits.
Worse, CBD is being produced without any regulation, resulting in products that vary widely in quality, said Marcel Bonn-Miller, an adjunct assistant professor of psychology in psychiatry at the University of Pennsylvania School of Medicine.
“It really is the Wild West,” Bonn-Miller said. “Joe Bob who starts up a CBD company could say whatever the hell he wants on a label and sell it to people.”
Cannabidiol is extracted from the flowers and buds of marijuana or hemp plants. It does not produce intoxication; marijuana’s “high” is caused by the chemical tetrahydrocannabinol (THC).
CBD oil is legal in 30 states where medicinal and/or recreational marijuana is legal, according to Governing magazine.
Seventeen additional states have CBD-specific laws on the books, according to Prevention magazine. Those are Alabama, Georgia, Indiana, Iowa, Kentucky, Mississippi, Missouri, North Carolina, Oklahoma, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Wisconsin and Wyoming.
Strong Evidence for Treating Epilepsy
Only one purported use for cannabidiol, to treat epilepsy, has significant scientific evidence supporting it.
Last month, a U.S. Food and Drug Administration advisory panel unanimously recommended approval of the CBD medication Epidiolex to treat two rare forms of childhood epilepsy.
“That’s really the only area where the evidence has risen to the point where the FDA has said this is acceptable to approve a new drug,” said Timothy Welty, chair of the department of clinical sciences at Drake University’s College of Pharmacy and Health Sciences, in Des Moines, Iowa.
For the rest of CBD’s potential uses, there is simply too little evidence to make a firm conclusion.
For example, some human clinical trials suggest that CBD could be effective in treating symptoms of anxiety, particularly social anxiety, Bonn-Miller said.
This is the potential use for CBD with the most evidence after usefulness in epilepsy, but “there’s a decent gap between those two,” he said.
“There have been clinical trials in adults, but a lot smaller than the epilepsy studies that have been done in kids,” Bonn-Miller said.
CBD’s usefulness as an anti-inflammatory medication is the next most promising, but those results come mostly from animal studies, experts said.
Most Other Uses Largely Unproven
The rest of the potential uses — as an antipsychotic, antidepressant or sleep aid “have all been studied in animals, with only one or two examples of studies in humans,” Bonn-Miller said.
And Welty said the studies that have featured humans for these other CBD uses have either been case reports or studies that did not compare results against a control group that did not use the oil.
“There’s no control, so it’s basically how do you know if we’re dealing with the true effect of the drug or just simply a placebo effect because somebody thinks they’ve been given a drug that will be beneficial?” Welty said.
There also are concerns about both the quality of CBD oil being produced and its potential side effects, the experts added.
Lack of Regulation Also Concerning
Because of the legally murky nature of marijuana, the FDA has not stepped in to regulate products like CBD oil, Bonn-Miller said. States are struggling to put regulations in place, but they don’t have the deep pockets of the federal government.
Meanwhile, a 2017 study led by Bonn-Miller found that nearly 7 of 10 CBD products didn’t contain the amount of marijuana extract promised on the label.
Nearly 43 percent of the products contained too little CBD, while about 26 percent contained too much, Bonn-Miller said.
“CBD is kind of a tricky drug because it’s not very well absorbed orally,” Welty explained. “Less than 20 percent of the drug is absorbed orally. If it isn’t made in the right way, you may not be getting much drug into your systemic circulation.”
Worse, about 1 in 5 CBD products contained the intoxicating pot chemical THC, Bonn-Miller and his colleagues found.
“That’s a problem because THC can increase anxiety. It can actually make seizures worse. Those are the sorts of things you need to be careful about,” Bonn-Miller said.
“If I were a consumer, purchasing it for myself or my kid, I would want to test it so that I knew what it actually had in it, because I couldn’t trust what was on the label,” Bonn-Miller concluded.
Potential Interactions With Other Meds
Studies on CBD also have raised concerns about possible interactions with other drugs.
For example, epilepsy studies found that “there were very clearly increases in the blood levels of some other anti-epileptic drugs when people were on CBD,” Welty said.
This could mean that people taking anti-epilepsy drugs alongside CBD will need to adjust their dosage downward to avoid side effects, Welty noted.
There also is some indication that CBD might harm the liver. About 10 percent of people taking CBD in studies had increases in liver enzymes, which would indicate possible liver damage, Welty said.
“About 2 to 3 percent of individuals taking CBD actually had to discontinue because their liver enzymes went so high it was of concern to the people running the study,” he said.
Welty recommends that people interested in CBD seek out a doctor who has read up on the extract and its potential uses.
“My bottom-line advice is people really need to be under the care of a health care provider who understands CBD. They need to be monitored and managed by that individual, and not just go out and buy CBD thinking it’s going to be the answer,” Welty said.
SOURCES: Marcel Bonn-Miller, Ph.D., adjunct assistant professor, psychology in psychiatry, University of Pennsylvania School of Medicine, Philadelphia; Timothy Welty, Pharm.D., chair, department of clinical sciences, College of Pharmacy and Health Sciences, Drake University, Des Moines, Iowa
CBD Oil: An Introduction
Medical patients swear by it. Researchers are intrigued by it. Government regulators are flustered by it. And investors are head over heels for it.
Medical patients swear by it. Researchers are intrigued by it. Government regulators are flustered by it. And investors are head over heels for it. CBD oil is the It-Medicine of the moment. A few years ago, hardly anyone knew about CBD oil. Today there’s a huge demand for it. Millions of people are taking CBD oil as a health supplement. But what exactly is it? Where does it come from? How is it made? And what should you know before you buy it?
Where Does CBD Oil Come From?
Cannabidiol ( CBD ) is one of more than 100 unique “cannabinoid” compounds that are found in the oily resin of the cannabis plant. The sticky, gooey resin is concentrated on the dense clusters of cannabis flowers, commonly called “buds,” which are covered by tiny, mushroom-shaped “trichomes.” This is where the magic happens.
Trichomes are specialized glandular structures that contain a treasure trove of oily, medicinal compounds, including CBD , tetrahydrocannabinol ( THC ), and various aromatic terpenes. Why does cannabis create these oily compounds? What does the resin do for the plant?
The oily trichomes protect the plant from heat and ultraviolet radiation. The oil also has antifungal, antibacterial and insecticidal properties that deter predators. The stickiness of the resin provides another defensive layer by trapping bugs.
As it happens, the same oily resin that protects the health of the plant includes components that are beneficial for human health. CBD , a non-intoxicating compound, has shown promise in treating and managing the symptoms of a broad range of diseases. Ditto for THC , CBD ’s intoxicating cousin.
CBD oil is extracted from the resinous trichomes of cannabis plants. There are many different cannabis “strains” or varietals. The amount of CBD present in the trichomes will depend on the particular variety of cannabis or hemp. Low resin industrial hemp, which is legally defined as cannabis with less than 0.3 percent THC by dry weight, has fewer trichomes – and therefore less oil – than high-resin cannabis varietals.
But most high resin cannabis strains these days are THC -dominant with little CBD . So choosing the appropriate CBD -rich cannabis chemovar, a variety of cannabis defined by its chemical constituents, is key for extracting CBD oil.
Trichomes are fragile structures that easily break off of the cannabis flower. Even rough handling is enough to shake off the trichomes. Making hashish or “kif” (hashish powder) involves manually removing the resinous trichomes by agitating the flower. Sometimes heat or pressure is applied to partially melt the trichomes together, turning the resin into a congealed slab, referred to as rosin, which can be smoked or ingested.
In addition to the resinous trichomes concentrated on the flowers and to a lesser extent on the leaves of the cannabis plant, there are the tiny sessile trichomes, which dot the stalk, but these contain hardly any oil or CBD . (Shaped like tiny inverted commas, non-glandular hairs without oil also cover the plant’s surface.) CBD is also absent in the roots or the seeds of cannabis and hemp. Companies that claim they derive CBD from hemp stalk or hemp seeds are making false claims.
How Is CBD Oil Made?
To make CBD oil, one must start with CBD -rich plant material. There are several ways to extract CBD oil from cannabis. Each method has its pros and cons. Some are safer and more effective than others.
After it is extracted from the plant and the solvent is removed, the CBD oil may be refined and formulated into a variety of consumable products – edibles, tinctures, gel caps, vape oil cartridges, topicals, beverages, and more.
The purpose of an extraction is to make CBD and other beneficial components of the plant (such as terpenes) available in a highly concentrated form. Because cannabinoids are oily by nature, separating CBD from the plant material will produce a thick, potent oil. The texture and purity of the oil depends largely on the method used to extract it.
CBD and the other plant cannabinoids are chemically classified as “terpenophenolic” compounds. To the non-scientists among us, this means that CBD is soluble in both oil and alcohol. Thus, the process of extracting CBD oil from cannabis often entails the use of a solvent that’s good at dissolving an oil or an alcohol-based compound. Solvents that are commonly used to extract CBD from cannabis include supercritical CO2 , ethanol, hydrocarbons (such as butane) and olive oil.
CO2 Extraction of CBD Oil
CO2 extraction is the most prevalent commercial method – as well as one of the safest ways – of separating CBD and other cannabinoids from cannabis biomass. At room temperature, carbon dioxide is a gas. But under high pressure and fluctuating temperature, CO2 liquifies while still maintaining the fluid dynamics of a gas. In this “supercritical” state, CO2 acts like a solvent, which flushes out the active ingredients from the plant matter.
This method is very effective because each compound can only be extracted by CO2 under specific conditions. Slight changes in temperature or pressure in a supercritical state allows for fine-tuning the extraction of CBD and other desirable plant components.
As the pressure drops, a crude, waxy, CBD -rich substance, golden in color, separates from the gas and deposits into a collection vessel. Afterwards, the golden oil undergoes a process known as “winterization,” which purifies and refines the extract to increase its quality and value. The plant waxes, which are not appropriate to include in certain kinds of products, are filtered out, resulting in a safe, clean, CBD -rich oil that is free of chlorophyll.
Supercritical CO2 extraction requires expensive equipment and a steep operational learning curve. But unlike combustible solvents, such as ethanol or butane, CO2 poses no danger of fire or explosion.
Ethanol Extraction of CBD Oil
The use of ethanol to extract medicinal compounds from cannabis and other plants has been a common practice in many cultures for centuries. In 1854, the U.S. Pharmacopeia recommended ethanol-based tinctures of “Indian hemp” to treat numerous ailments, including neuralgia, depression, hemorrhage, pain and muscle spasm.
These odiferous tinctures were a standard part of American health care prior to the passage of the Marihuana Tax Act of 1937, which prohibited all forms of cannabis consumption. But homemade cannabis tinctures persisted as an underground folk medicine, particularly in marginalized Latino communities, despite federal law.
In recent years, ethanol has re-emerged as a popular means of extracting cannabis oil, in general, and CBD oil, in particular. Whereas a tincture made from a cannabis extract could be equal in potency to the original flower, a concentrated version of the same tincture will be much more potent. Today, food-grade grain alcohol is a widely used solvent for creating very potent, high-quality CBD -rich oil, which is suitable for oral ingestion.
Ethanol extracts available in medical cannabis dispensaries are typically referred to as Rick Simpson Oil (aka RSO ) or Full-Extract Cannabis Oil ( FECO ). In order to make RSO or FECO , cannabis flower is soaked in ethanol, agitated, and strained; then the residual oil is gently heated until all that remains is a viscous, highly concentrated goo infused with cannabinoids, which can be difficult to dose accurately, given how thick it is.
Often sold in plastic, needleless syringes to make dosing and administration a little easier, RSO should contain the full spectrum of cannabinoids extracted from the plant. This means that a small amount THC will also be present in a CBD -rich ethanol extraction. Consumers are cautioned not to ingest a dose larger than a small grain of rice. With this type of cannabis oil, in particular, it’s always best to start low and go slow.
Hydrocarbon Extraction of CBD Oil
Using hydrocarbon solvents – such as butane, hexane and propane or mixtures thereof – to extract CBD from cannabis has major advantages as well as distinct disadvantages compared to other methods of manufacturing CBD oil. When properly implemented, this extraction technique is a very effective at separating cannabinoids and terpenes from unwanted cannabis components (e.g., chlorophyll), while preserving the unique scent and significant therapeutic attributes of the plant.
Potent cannabis concentrates made with hydrocarbons may resemble tree sap, ear wax, or brittle candy in texture. The product known as “shatter” (so named because of its glass-like appearance and the manner in which it breaks) is consumed via inhalation by using a “dab rig” or a high temperature vaporizer.
But butane and other hydrocarbons are highly flammable, neurotoxic solvents. If these solvents aren’t fully purged from the CBD oil extract, their consumption can be harmful – especially for someone with a compromised immune system. In addition to leaving toxic residues in the oil, unsafe manufacturing processes involving hydrocarbons have been known to cause deadly explosions.
Making Your Own CBD Oil
Project CBD strongly discourages home extraction using flammable solvents. There are much safer options for making a CBD oil extract in one’s own kitchen.
A 2013 study by Luigi L. Romano and Arno Hazekamp evaluated the efficacy and purity of five cannabis extraction solvents, including ethanol, naphtha (a harsh industrial poison that should be avoided), and olive oil. The authors found comparable efficiency between all the solvents but noted that olive oil, a nontoxic solvent, was better at extracting terpenes along with the cannabinoids. Moreover, according to Hazekamp, “You won’t blow yourself up making cannabis-infused olive oil.”
Olive oil extraction is safe, simple and straightforward. It’s also inexpensive. And you can do it yourself. Heating the plant matter in an oven will decarboxylate the cannabinoids, turning THCA into THC and CBDA into CBD . Steep the flower and leaves in the olive oil; then sift, strain, and separate the oil from what’s left of the herb. Cannabis-infused olive oil — whether CBD -rich or THC -dominant — is perishable and should be stored in a cool, dark place so it doesn’t turn rancid.
One can also extract CBD from cannabis by using other lipid solvents, including avocado, coconut or MCT [medium chain triglyceride] oil. Hemp seed oil is another effective extraction solvent and a carrier vehicle that mixes well with CBD .
But be forewarned about CBD product companies that claim they get their CBD from hemp seeds. While hemp seeds are an excellent source of protein-rich, omega 3 fatty acids, the seeds themselves don’t contain CBD , THC or any other cannabinoids. Trace amounts of cannabinoids may be present in oil pressed from hemp seeds if the seed covering, the bract (where resin can cling), isn’t thoroughly rinsed and removed prior to the extraction process.
Unregulated CBD Oil Products
To reiterate: CBD oil in not the same as “hemp oil” or “hemp seed oil.” Some companies are manufacturing inferior products by spiking hemp seed oil with a CBD isolate. Such products lack the synergistic array of beneficial components found in full-spectrum CBD -rich oil.
Unfortunately, there is little oversight for manufacturing hemp-derived CBD products, which can lead to confusion and deception. Many hemp-derived products are mislabeled as to CBD and THC content. And poorly processed CBD oil may be contaminated with dangerous solvent and pesticide residues, thinning agents, corn syrup, artificial flavors and colors, and other toxins.
If possible, it’s better to obtain CBD oil products from licensed dispensaries in states that have legalized cannabis for therapeutic or personal use. These states are likely to have stricter safety standards for CBD oil products than states or countries that refuse to regulate the booming CBD industry. Read the ingredients carefully before purchasing a CBD oil product, and look for evidence of laboratory tests and verification of CBD concentrations when buying a CBD remedy or supplement.
Zoe Sigman is Project CBD ’s Program Director and the Science Editor at Broccoli Magazine.
Copyright, Project CBD . May not be reprinted without permission.