And last but not least, CBD triggers apoptosis, which is programmed cell death. Researchers have found this ability during animal and laboratory models; these properties apply to both CBD and THC (4).
When the liver gets damaged, inflamed, or dysfunctional, the body starts to release more endocannabinoids to solve the problem. A healthy liver is correlated with a modest activity of the endocannabinoid system. In fact, this particular organ has a relatively low concentration of the ECS components.
To this day, studies on cannabinoids and their effect on liver cancer show that cannabinoids can both prevent the dividing of tumor cells and kill cancer cells while protecting the healthy ones. Besides stopping cancer proliferation, there are several mechanisms CBD uses to help tackle liver cancer.
CBD Oil for Hepatic Ischemia
However, one of the caveats of this study was that it tested the maximum recommended daily dosage for humans. While all mammals share the same endocannabinoid system, mice and humans are different physiologically. The size of the liver is just one of the many variables that should be taken into consideration when evaluating the safety of CBD in human subjects.
According to researchers from the University of Arkansas, who investigated the effects of treatments of various doses of CBD on a group of 8-week-old mice, the study addressed the problem of a “lack of comprehensive toxicological studies devoted to CBD safety that are critical for further marketing of CBD and CBD-containing products.” (2)
First, it provides anti-metastatic actions, preventing distant tumor masses from forming in the liver.
Ischemia is a very common injury that occurs as an aftermath of liver surgeries and liver transplantations. It involves major inflammation and is responsible for deaths in the case of transplants and rejections. Oxidative stress can worsen the condition.
The compound can cause liver injury, interact with other drugs, and increase the risk of drowsiness and sedation when used with alcohol, the FDA said. Studies using lab animals have also shown negative impacts on the male reproductive system, though the takeaway for human patients remains unclear, the FDA said.
The FDA sent letters warning 15 companies for illegally selling CBD-containing products. The federal agency also updated its position to clarify that the substance increasingly infused in pills, lotions, food products and wellness beverages “has the potential to harm you, and harm can happen even before you become aware of it.”
The only CBD product approved by the FDA is the prescription drug Epidiolex, which treats pediatric epilepsy. It’s illegal to market CBD as a dietary supplement.
— — Amy Abernethy, FDA principal deputy commissioner
Warne, who received his diagnoses after his grandfather’s death, wonders whether he was misdiagnosed. But the results he has seen since taking CBD, he said, have been “moderately positive.” “I’ve been feeling great since I got off my meds,” he said.
The agency also provided a list of potential side effects related to CBD, including sleepiness, diarrhea and/or a decrease in appetite, and mood changes such as agitation and irritability.
“I still don’t think it’s so harmful that I shouldn’t use what I have,” Warne said in response to the new FDA warning. “But it certainly makes me question how settled the science is … and maybe it’s not as ironclad as I thought it was before.”
What is CBD oil?
As determined by the studies done on Epidiolex®, CBD is metabolized by the liver. People with nonalcoholic steatohepatitis (NASH) are encouraged to limit over-the-counter (OTC) medications to avoid stressing the liver.
To further complicate the question, products with CBD oil may not give the exact amount listed on the package . Depending on the brand, the consumer may be using much more or less than they think. This is especially true of OTC supplements and e-cigarettes.
Cannabidiol oil is extracted from the hemp plant, which is in the same family as marijuana. Unlike THC in marijuana, CBD does not cause a “high” or chemical dependence. CBD that is extracted from the hemp plant is legal, but individual states have laws to regulate it.
How much CBD is too much?