The combination of CBD and THC is a powerful treatment for nerve damage and neuropathic pain. Here is what you need to know about CBD:THC ratios for neuropathy. Research has shown CBD alleviates neuropathic pain that didn’t respond to conventional treatment. View the best CBD oils for nerve pain.
Best CBD:THC Ratio For Neuropathy
Learn how to use CBD & THC together for neuropathy and which ratio is best.
The main active compounds in cannabis, cannabidiol (CBD) and delta 9 tetrahydrocannabinol (THC), offer pain relief and comfort to those suffering from nerve pain.
Nerve pain or neuropathy is often treated with medications made for other disorders like seizures and depression. CBD and THC make great alternatives with less side effects, less risk for tolerance and addiction, and better efficacy.
While each cannabinoid has its own benefits as an anti-inflammatory, analgesic, and muscle relaxant, research suggests that they offer more potent effects towards supporting neuropathic conditions when combined.
The best CBD:THC ratio for neuropathy is 1:1 — where there is an equal amount of these cannabinoids in each dose.
Here’s everything you need to know about the best CBD: THC ratio for nerve pain based on recent studies.
Table of Contents
What is Neuropathy? What Causes It?
Neuropathy refers to nerve pinching, compression, and damage resulting in pain.
There are many different causes of neuropathy, ranging from traumatic injuries to degenerative disorders like multiple sclerosis or cerebral palsy.
The condition leaves patients with significant pain, numbness, and, in severe cases, a reduction in autonomy and paralysis.
Neuropathic pain is especially difficult to treat. Conventional painkillers like acetaminophen don’t normally work that well for this type of pain because they target inflammation. Because the pain originates from the neurons themselves, reducing inflammation has little impact on pain.
Benefits of CBD & THC For Neuropathy
CBD has been widely studied for addressing neuropathy or nerve pain.
CBD on its own may be helpful for peripheral neuropathy, with patients reporting less pain after taking CBD.
CBD has been observed to reduce inflammation in neuropathy patients by interacting with the α3-glycine receptors, which are responsible for our sense of pain .
The Benefits of THC and CBD For Neuropathy Include:
- Reducing inflammation
- Managing chronic pain
- Relieving symptoms of depression
- Supporting healthy sleep quality
- Promoting nerve regeneration
Will CBD & THC Interact With My Neuropathy Medications?
Neuropathy is often treated with prescription medications — many of which may interact negatively with CBD.
Make sure to always ask your doctor about interactions with any other medications you take to treat your neuropathy, especially antidepressants.
Common neuropathy medications and their potential interaction with CBD:
1. Opiate Painkillers
Opiates are commonly used to treat nerve pain. They’re considered to be one of the strongest classes of prescription painkillers available. They work by targeting the opiate receptors in the central nervous system. This effect blocks the transmission of pain heading from the body to the brain.
CBD may interact with opioid pain medications. This supplement has a similar effect as opiates on inhibiting neurological function and may compete for metabolism in the liver. Both of these effects could lead to an increased risk of side effects and overdose.
Always speak to your doctor about using CBD if you’ve been prescribed an opioid medication.
Common opiates used for neuropathic pain include:
- Buprenorphine (Cizdol & Brixadi)
- Pethidine (Meperidine & Demerol)
- Fentanyl (Abstral & Actiq)
- Hydrocodone (Hysingla ER, Zohydro ER & Hycodan)
- Hydromorphone (Dilaudid)
- Methadone (Methadose & Dolophine)
- Morphine (Kadian & Roxanol)
- Oxycodone (Percodan, Endodan, Roxiprin, Percocet, Endocet, Roxicet & OxyContin)
- Tramadol (Ultram, Ryzolt & ConZip)
Long-term neuropathic pain often leads to depression. Lowered quality of life, poor sleep, and job loss all contribute further to this effect.
If you’ve been prescribed antidepressants, it’s important to speak with your prescribing doctor about CBD and THC first. Both compounds can interfere with the metabolism of drugs like SSRIs and SNRIs and lead to negative side effects.
THC is especially likely to interact with these substances in a negative way.
Common prescription antidepressants include:
- Citalopram (Cipramil & Celexa)
- Dapoxetine (Priligy)
- Escitalopram (Cipralex & Lexapro)
- Fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra & Oxactin)
- Fluvoxamine (Faverin)
- Paroxetine (Seroxat)
- Sertraline (Lustral)
- Vortioxetine (Brintellix)
- Atomoxetine (Strattera)
- Desvenlafaxine (Pristiq, Khedezla)
- Duloxetine (Cymbalta, Irenka)
- Levomilnacipran (Fetzima)
- Milnacipran (Savella)
- Venlafaxine (Effexor XR)
CBD & THC Ratios: What Dose Should I Take?
The best CBD:THC ratio for neuropathy is 1:1+, meaning equal parts CBD and THC or less CBD than THC.
Keep in mind that dosing and ratio are two very different things.
The dose refers to how much of the compounds you’re taking, and it’s typically measured in milligrams. There is no one-size-fits-all approach to dosing for neuropathic pain, but higher doses (50 mg +) have been shown to provide the most relief towards pain and inflammation.
To determine your doses, you can try our dosage calculator. This will give you a rough estimate of how much CBD you should consume depending on your weight and desired strength, but you can expect to experiment with your doses as cannabinoids affect individuals differently.
CBD and THC gummies and oils are easy to dose using ratios because you can cut the gummies or measure oil in mL. However, you can also buy CBD:THC ratio products that are already mixed for you.
Other CBD:THC Ratios
The best ratio of CBD to THC is a hot topic lately. While we already have a lot of data available for the benefits of both these cannabinoids for certain conditions — there’s very little information about what the optimal ratio of each one is when used in conjunction.
As more research comes to light on the intricate synergy between these two compounds, scientists are uncovering insight into ways we can get even more effectiveness out of cannabis.
Here are some of the other optimal CBD to THC ratios based on the current evidence so far:
Final Thoughts: Best CBD:THC Ratio For Neuropathy
The best CBD:THC ratio for neuropathy is 1:1 with equal parts THC to CBD.
Both THC and CBD are useful in managing pain from this condition. Taken together, the effects become even stronger.
There are several pharmaceutical medications using CBD and THC for treating pain — the majority of which use this same 1:1 ratio.
You can achieve this ratio by taking equal doses of CBD oil and THC oil or by mixing roughly equivalent doses of CBD or THC vape pens, capsules, gummies, or other products. You don’t have to use a premade CBD:THC product to get the benefits of this combination.
Best CBD Oil For Nerve Pain: Benefits & Dosage For Neuropathic Pain
Only 40% to 60% of patients able to find partial relief from their symptoms with conventional treatments.
Recent evidence suggests CBD oil may be a powerful natural treatment option for nerve-related pain.
Learn how it works & how to use it.
The human body is full of sensors leading to the brain. They sense temperature, touch, and tissue damage, and relay that information back to the brain for processing.
Neuropathic pain can be the result of damage to the nerves or pain sensors.
Learn what makes CBD so useful for treating neuropathic pain, how to use it effectively, and what other measures you can do to get the best chances of finding relief from your pain.
So, without further ado, let’s get into it.
MEDICALLY REVIEWED BY
Updated on October 20, 2021
Table of Contents
- Can CBD Oil Help With Neuropathic (Nerve) Pain?
- What is a Spinal Cord Injury?
$49 – $229
Royal CBD Oil 30 mL
5 / 5
|Total CBD:||500 – 2500 mg|
|Potency:||16.6 – 83.3 mg/mL|
|Cost per mg CBD:||$0.12 – $0.18|
Can CBD Oil Help With Neuropathic (Nerve) Pain?
CBD and other cannabinoids offer relief from various causes of neuropathic pain in humans [2, 3].
It offers most of these benefits through its ability to interact with the endocannabinoid system (ECS).
The ECS consists of a series of receptors and eicosanoids (called endocannabinoids) that regulate homeostasis (balance) throughout the body. There are endocannabinoid receptors found on virtually every organ in the human body, with the highest concentration in the central nervous system.
The endocannabinoid system functions like “read receipts” used in text messages.
When the nerves send a message, the receiving nerve cell uses the endocannabinoid system to tell the sending nerve that the message was received.
This system keeps the entire nervous system in constant feedback with itself and prevents sending the same message more than once — which is essentially what happens when we experience neuropathic pain.
CBD also supports nerve pain by reducing inflammation, activating the vanilloid pain receptors, and alleviating many of the common side effects of nerve pain.
The benefits of CBD oil for neuropathic pain include:
- Protects the nerve cells & brain
- Supports nerve cell regeneration
- Blocks pain transmission
- Regulates electrical activity in the brain
- Alleviates anxiety & depression
- Supports sleep
What’s The Effective Dose of CBD For Neuropathic Pain?
When it comes to treating neuropathic pain — a notoriously difficult type of pain to alleviate — a higher strength of CBD is generally recommended. Most of the research showing benefits from CBD noted an abnormally large dose of the compound to achieve this success.
For this reason, it’s a good idea to work out the dose yourself to find out what’s best for you and your symptoms.
You can use our CBD oil dosage calculator to find the best dose based on your weight and desired level of effects.
Start small and increase the dose every day until you either experience relief from symptoms — meaning you’ve found your dose — or experience side effects. If you experience side effects, you may need to dial the dose back to the last side-effect-free dose.
If you’re still not getting any reduction in pain symptoms with this dose, you may need to combine CBD with other forms of pain management — after consulting with a doctor, of course.
CBD Dosage Calculator
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What Are The Side-Effects of CBD?
Although CBD has been proven to be highly safe many times over, it’s important to know about the potential side effects it may produce.
Everybody is different, and what works for one person doesn’t always work the same way for another.
Here are some of the most common side-effects of CBD:
Which Type of CBD Should I Use?
CBD comes in all different forms — not all are going to work for every condition.
1. CBD Oils & Tinctures
CBD oils and tinctures provide the easiest methods of taking CBD. All you need to do is measure out the desired dose (more on this later) and pop it into your mouth. You can choose to hold the oil/tincture under your tongue for faster absorption or swallow it right away — both will work well.
2. CBD Capsules
CBD capsules are another excellent dosing option you can employ. Capsules are small and easy to carry, deliver standardized CBD doses, and have great bioavailability. They’re also an excellent option for people who don’t want to taste the CBD oil — which can have an earthy, undesirable taste in some cases.
3. Topical CBD Products
Topical CBD is another good option, but only if the source of your neuropathic pain is close to the surface of the skin. It’s recommended that you use it alongside internal forms of CBD, such as capsules, edibles, or oils. This is because the cannabinoids in topical CBD products won’t reach the spinal cord and brain where most of the pain relief comes from when treating neuropathic pain.
4. CBD Edibles
CBD Edibles, including gummies or baked goods, are certainly a fun way of taking CBD — but they’re often inconsistent with dosing (with the exception of gummies). The dosages listed are estimates, and the actual CBD content inside can vary significantly.
For this reason, we don’t recommend relying on CBD edibles as your everyday maintenance dose of CBD for neuropathic pain.
What is Neuropathic Pain?
Neuropathic pain is a type of pain involving damage to or dysfunction of the nerves and somatic sensors found throughout the body.
Any damage to or dysfunction of the nerves and sensory tissues can send pain signals to the brain. These signals warn the body of real damage or dysfunction, but they can also be caused by false messages sent to the brain.
These messages warn the brain of damage that may or may not exist. This makes neuropathic pain difficult to treat, especially when the underlying cause can’t be identified.
1. Central Neuropathic Pain
The central nervous system is any part of the nervous system inside the brain and spinal cord. This is separated from the peripheral nervous system by a semipermeable barrier called the blood-brain barrier.
Central neuropathic pain, therefore, involves pain originating from nerves located inside the central nervous system.
It’s caused by conditions such as:
2. Peripheral Neuropathic Pain
The peripheral nervous system involves any part of the nervous system outside of the brain and spinal cord. This includes all the nerves in the limbs, abdominal cavity, legs, and face.
Often, when a nerve becomes damaged, the repair process may not go as planned. Instead of returning the nerve to the way it was before the damage, the nerve becomes unusually sensitive and will send pain signals to the brain when it shouldn’t.
The original damage can happen from many different causes, primarily traumatic injuries or specific viruses that target the nerve cells directly — such as herpes virus or shingles.
This type of pain is caused by conditions such as:
3. Mixed — Peripheral and Central Neuropathic Pain
Mixed neuropathic pain involves pain stemming from nerves found both inside the central nervous system and inside the peripheral nervous system.
Causes for mixed neuropathic pain include:
- Chemotherapy treatments
- HIV and other viral infections
- Heavy metal toxicity
What Are The Causes of Neuropathic (Nerve) Pain?
Neuropathic pain is caused by damage or dysfunction of the nerve cells. There are many causes for nerve damage in the body, such as:
Treatments for Neuropathic Pain
- Antidepressants (SSRIs, SNRIs, and tricyclic antidepressants)
- Opiate pain medications (morphine, fentanyl, tramadol, and methadone)
- Surgical nerve blocks (severe cases only)
- Topical analgesics (lidocaine)
CBD For Spinal Cord Injury
Spinal cord injuries can have debilitating and life-altering consequences. Injuries can cause varying levels of paralysis, spasticity, loss of sensation, muscle weakness, and nerve pain that can persist for the rest of that person’s life.
There are some treatments available for this condition, most of which are supportive — helping those affected manage pain, depression, and other side-effects of the condition.
CBD cannot cure a spinal cord injury — however, it does likely offer a great deal of support for those affected by managing symptoms and promoting the repair of nerve cells in the damaged areas of the spinal cord.
There’s also some indication that CBD can support the recovery process — lowering the severity of side effects and improving motor function in the affected nerves .
The Benefits of CBD Oil For Spinal Cord Injury Includes:
- Managing chronic pain
- Relieving symptoms of mild to moderate depression
- Adjunctive treatment to prevent antibiotic resistance during lung infection
- Alleviating insomnia
- Promoting nerve regeneration
- Possibly reducing the extent of nerve damage from the incident
What is a Spinal Cord Injury?
The spinal cord is an extension of the brain. It contains high concentrations of nerve cell tracts that send and receive messages between the body and the brain. Any damage to the spinal cord can result in serious consequences, including paralysis, spasms, neuropathic pain, or loss of organ function.
The spinal cord contains millions of nerve “intersections” that distribute signals to every part of the body. The area of the spinal cord that is damaged will determine what side-effects develop and where.
For example, if the region of the spine containing the nerves that control leg muscles is damaged, it means that there will be a weakness or complete loss of function in those muscles and sensory deficits in one or both legs.
Spinal Cord Injury Symptoms
Types of Spinal Cord Injury
Depending on how severe the injury is, there are three main classifications that doctors use to describe the condition:
- Incomplete spinal cord injury — involves damage that hasn’t completely inhibited nerve transmission past the site of injury.
- Complete spinal cord injury — damage to the spinal cord is severe enough that no nerve signals can pass across the site of injury.
- Brown Séquard Syndrome— damage to exactly one half section of the cord, either left or right hemisection.
There are also several other types of spinal cord injury such as dorsal column lesion, irregular lesions, small or large central lesion, tumor of the dorsal root, or tumor of the meninges or bone.
The Location of the Spinal Cord Injury Matters
Nerves leave the brain and head down the spinal cord in bundles and pairs. They branch off at various points along the way to go to their target organs, and some tracts will cross sides.
The location of the damage to the spinal cord will determine which areas of the body are affected.
Complete damage of the spinal cord will prevent all nerves below the damaged point to stop receiving or sending messages. Therefore, to classify the level of injury, doctors will assess the lowest levels of different sensations and functions of the nerves in the spinal cord.
There are four main divisions of the spinal cord — organized according to the vertebral column. The vertebral column starts at one at the base of the skull and goes all the way to the coccyx. The spinal cord, in fact, actually ends between vertebrae L1-L2, and is followed by a bundle of nerves called the cauda equina the rest of the way down.
Causes of Spinal Cord Injuries
What the Research Says
In 2012, researchers conducted a study on the use of CBD for spinal cord injuries in rats . Rats were either placed in the treatment group and given CBD, or into the control group where no treatment was given. At the end of the six-day study, rats in the CBD treatment group had significant improvements in motor function and reduced injury side-effects than rats in the no-treatment group. Therefore, the researchers conducting this study concluded that CBD might be a useful treatment option for spinal cord lesions (injuries).
Another study used a survey that was handed out to 10 spinal cord injury patients at the Spinal Cord Injury ward of the Miami V.A. Hospital who were using marijuana to treat their symptoms. The survey was kept confidential and involved questions about the most common symptoms of the condition and how marijuana use affected them.
Results of This Survey Listed:
|Symptoms||Made Worse||Made Better||No Effect||Distraction||Not Applicable|
THC has also offered benefits for spinal cord injuries. For this reason, a full-spectrum cannabis extract containing both CBD and THC is considered the best option.
Potential Benefits of THC for Spinal Cord Injuries
- Reduces muscle spasms involved with spinal cord injuries 
- Improves bladder control in spinal cord injuries 
- Reduces pain associated with spinal cord injuries 
THC remains illegal throughout most of the world, so it may be difficult to find products containing more than 0.3% THC concentration. Further robust studies will be needed to better characterize standard effects and determine efficacy.
Key Takeaways: Does CBD Oil Work For Neuropathic Pain?
The causes of neuropathic pain can range from neurological issues such as multiple sclerosis or a stroke to nutritional deficiencies and diabetes.
No matter what’s causing neuropathic pain, the benefits of CBD remain much the same.
CBD can support neuropathic pain in the following ways:
- Increases anandamide levels
- Activates the vanilloid receptors
- Inhibits inflammation that may be causing neuropathic pain
- Mildly activates the opioid receptors in the spinal cord and brain
When it comes to treating neuropathic pain, a higher dose is usually recommended — however, this can vary from person to person. Whenever using CBD for the first time, it’s wise to start low and increase slowly over time until you receive the benefits you’re looking for.