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The CBD Pillow uses a dispersion of microencapsulated cannabidiol. Microencapsulation is a new, innovative process in which microscopic droplets of CBD are wrapped with a protective polymeric coating. These miniature containers protect the CBD from evaporation, oxidation and contamination until their release is triggered.
After the CBD is encapsulated, the quality, integrity, and shape of the capsules are checked via SEM (scanning Electron Microscope) analysis, while the size is evaluated using a particle size analyzer.
It’s a transdermal application of CBD. We’ve had extensive 3rd party testing performed using a Franz cell test on skin, which determined the CBD absorption effectiveness. Here’s our results:
After extensive laboratory testing, the results determined that after 20 WASHES, the CBD Pillow fabric still contained up to 14% above the guaranteed amount of CBD.
Once applied to the fabric in the CBD Pillow, the microcapsules break through friction and release the CBD to be absorbed through skin and hair follicles.
The jury may still be out regarding plenty of supposed medical uses for CBD, a non-psychoactive compound found in cannabis, but researchers are certainly working hard investigating the cannabinoid’s effect on everything from heroin addiction to Parkinson’s tremors. One significant challenge scientists face in researching CBD’s therapeutic uses is the fact that oral CBD formulations have terrible rates of absorption.
Alongside this, the researchers tested whether these CBD microcapsules could be accompanied by other absorption-enhancing compounds to enhance brain bioavailability. In this instance the researchers tested co-administration with a bile acid called deoxycholic acid (DCA). Animal tests were then conducted to measure CBD absorption levels, comparing the CBD microcapsules alone, the microcapsules in combination with DCA, and traditional CBD oil.
Interestingly, while plasma concentrations of CBD were higher in the short-term in the microcapsule cohort compared to the CBD oil control, CBD concentrations in the brain only spiked significantly when the cannabinoid was administered with DCA. The researchers suggest the microcapsule/DCA combination led to a “remarkable 40- and 30-fold increase compared to the naked CBD oil and CBD capsule groups, respectively.”
“The potential effect of DCA on the drastic reduction in brain CBD concentration is an interesting finding that requires further investigations,” the researchers conclude in the new study. “Research suggests that bile acids may promote cellular uptake and clearance of lipoproteins, however, the effects of bile acids such as DCA on tissue clearance or lipophilic drugs such as CBD have yet to be defined.”
CBD oil, for example, when ingested orally can result in plasma and tissue bioavailability as low as 6 percent. Sublingual dosing, or using varieties of inhalation methods, can result in higher levels of absorption but there still remains a huge inconsistency in bioavailability from person to person. For researchers trying to investigate CBD’s potential therapeutic uses this dosage issue is a particular problem, especially for those exploring the compound’s effects on the brain.