However, CBD and other plant cannabinoids can potentially interact with many pharmaceuticals. For example, the activity of liver enzymes such as cytochrome P450 is impacted. More than 60 percent of marketed pharmaceuticals are metabolized by this group of enzymes. At high enough dosages, CBD will temporarily deactivate these liver enzymes, thereby altering how a wide range of compounds is metabolized. The exact mechanisms are unknown and more human studies, which monitor CBD-drug interactions are needed (22). PwMS who are taking any prescription medications are strongly advised to consult with a medical professional.
The cannabis plant contains many biologically active chemicals, including
Serious drug interactions have not been seen with CBD in combination with any other drugs.
Can a Cannabidiol User Test Positive for Marijuana?
Based on the following considerations, it is our opinion that CBD supplementation maybe advisable for PwMS to reduce fatigue, pain, spasticity, and ultimately improve mobility. An overview of the potential impacts of CBD on mobility of PWMS is show in Figure Figure1 1 .
60 cannabinoids (3). Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are typically the most concentrated chemical components of cannabis and believed to primarily drive therapeutic benefit. There is evidence that CBD has a number of beneficial pharmacological effects (4, 5). It is anti-inflammatory, antioxidative, antiemetic, antipsychotic, and neuroprotective. The review of 132 original studies by Bergamaschi et al. (6) describes the safety profile of CBD by highlighting that catalepsy is not induced and physiological parameters (heart rate, blood pressure, and body temperature) are not altered. Moreover, psychomotor and psychological functions are not negatively affected. High doses of up to 1,500 mg per day and chronic use have been repeatedly shown to be well tolerated by humans (6). Additionally, there is also evidence that CBD may reduce the negative psychotropic effects, memory impairment, and appetite stimulation, anxiety and psychotic-like states of THC while enhancing its positive therapeutic actions (7, 8).
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that affects an estimated 2.3 million people worldwide (1). The symptoms of MS are highly varied but frequently include pain, muscle spasticity, fatigue, inflammation, and depression. These symptoms often lead to reduced physical activity, negatively impact functional mobility, and have a detrimental impact on patients’ quality of life. Although recent years have seen significant advances in disease modifying therapy, none of the current treatments halts or cures MS related symptoms (2). As a consequence, many people with MS (PwMS) look for alternative and complementary therapies such as cannabis.
A major concern is the often labeling accuracy of CBD extracts. Bonn-Miller et al. (23) found a wide range of CBD concentrations among CBD products purchased online. The tested products contain 26% less CBD than labeled, which could negate any potential clinical benefit. The over labeling of CBD products and that THC was detected (up to 6.43 mg/mL) in 18 of the 84 samples tested suggest that there is a need for federal and state regulatory agencies to take steps to ensure label accuracy of CBD products sold online and in dispensaries.
<p>Hi all.. Great article. I’ve been poking around on a few Ms forums and i’m actually a little distressed that not that many people seem to know about CBD oil. My wife might potentially be diagnosed or in the beginning stages of MS. As soon as the MD suggested he needs to "rule out" MS I put her on CBD oil. Just some weak stuff I ‘ve had for a while. Waiting for the good stuff in the mail now. The key word for me is neuro-protectant. <br> <br> My personal testimony for CBD relates to my cat. When we got her, she was having seizures like it was the thing to do. We pumped her full of drugs to knock her out and break the cycle. Still after she slept for a day and was on meds regular, they always came back. I started giving her my own personal stash of CBD oil in a dropper. No more seizures. No other meds. Just cbd everyday. We have some specifically for animals now. My vet said CBD is the only thing that prevents him from having seizures related to a head injury. <br> <br> My wife symptoms have dissipated in the three days she has been taking it. I also put her on some high quality supplements from ONNIT to make sure she gets everything she needs. I spoke to a naturopatic doctor and he suggested 50mg per day would be a good dose to start with. <br> <br> Anyway.. I wrote this a little hurried but I wanted to get it off my chest.</p>
Devin Garlit Moderator
<p>Hey Devin, just discovered you and your writing, it’s so on point. with everything! Where do you get your oil from?</p>
Devin Garlit Moderator
<p>Thank you MartinH! Sorry for the delayed response! I agree, it does seem to be under most people’s radar. Hopefully that begins to change. I hope your wife is doing well on it!</p>