According to the investigators, men provided 300 mg of CBD exhibited less anxiety than those given a placebo. Interestingly, those provided 100 mg or 600 mg of CBD oil did not.
Instead, CBD is thought to influence other receptors, including opioid receptors that regulate pain and glycine receptors involved in the regulation of the “feel-good” hormone and neurotransmitter serotonin.
Scientists believe that CBD reduces nerve pain by binding to glycine receptors in the brain that regulate the speed at which nerve signals pass between nerve cells.
CBD oil can interact with certain medications, including some drugs used to treat epilepsy. CBD inhibits an enzyme called cytochrome P450 (CYP450), which metabolizes certain drugs. By interfering with CYP450, CBD may either increase the toxicity or decrease the effectiveness of these drugs.
The findings suggest that CBD oil may be a suitable complementary therapy for people whose hypertension is complicated by stress and anxiety. However, there is no evidence that CBD oil can treat hypertension on its own or prevent hypertension in people at risk. While stress is known to complicate high blood pressure, it cannot cause hypertension.
True CBD products are prepared from hemp plants, which can contain trace quantities of THC unless that’s removed during extraction. If a product contains high levels of THC, you might experience side effects like dry mouth, hunger, or altered mood and thinking.
You have complications with your liver. (Could be important) This warning is speculative, but people who have liver problems might want to be cautious about their CBD intake. During the clinical trial of Epidiolex, children taking CBD were more likely to have elevated liver enzymes (ALT and AST aminotransferases). In CBD’s defense, all of these children were also taking pharmaceuticals known to damage the liver. It’s currently unclear whether CBD directly affects the liver — or if the interaction with pharmaceuticals (mentioned above) results in higher bloodstream levels of liver-damaging prescription drugs. However, just to be safe, if you suffer from liver problems or take medication that is hard on your liver, you might want to monitor your liver enzymes when introducing CBD into your daily routine. Epidiolex additionally suggests that people with liver impairments slowly increase their CBD doses . They also reported that elevated liver enzymes were primarily observed in children taking the maximum dose, and lower doses (680 mg or less per day for a 150-pound person) posed a much lower risk.
Clinical trials give patients high-quality, safe products which contain a reliable quantity of CBD. The Epidiolex side effects are ones you might expect from a high dose of a very pure product. On the other hand, because the supplement industry in the US isn’t heavily regulated, if you purchase CBD from dishonest or potentially unsafe manufacturers, you might experience very different side effects. In fact, when scientists recently tested a variety of publicly-available CBD products, only 31% were accurately labeled .
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When looking through the thousands of scientific articles referencing CBD, it’s very difficult to find any evidence of dangerous side effects or contraindications. However, widespread use of concentrated CBD is a very new phenomenon, and your safety is our priority.
Although CBD has been deemed safe by the WHO and other health organizations, not enough experiments have been done to identify if there are any populations for whom CBD is unsafe. Instead of taking that as a free pass to tell everyone to take CBD (like most other CBD companies), we think this makes it even more important to scour the scientific literature for any warning signs. Because we value your safety first, we put together a list of all the conditions we could find that might deserve special consideration.
You’re immune compromised. (Most evidence disproves this concern) CBD is known as an immunomodulator because it can calm down a hyperactive immune system , but some worry this could harm people whose immune systems are already impaired, like HIV sufferers. Although we don’t have evidence specifically testing CBD against this fear, many studies have been done using the whole cannabis plant. Research shows that cannabis helps relieve pain and other HIV-related symptoms without causing severe side effects . And when marijuana is tested against specific HIV symptoms like liver fibrosis, cannabinoids do not appear to worsen it . Although current evidence suggests that CBD could be more helpful than harmful for immune-compromised individuals, the jury is still out.
For many of us, it may seem as though cannabidiol (CBD) sprang up out of nowhere. Within a few short years, this obscure molecule found in cannabis plants has moved from near-anonymity to a cure-all embraced by millions.