CBD Gummies And Covid

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Early Studies Suggest CBD May Help Prevent COVID-19 Medical formulations of the compound cannabidiol — known as CBD — have shown promise as a way to prevent COVID-19. Medical formulations of New evidence is adding support to the theory that cannabis derived CBD may help those suffering from the severe lung inflammation that occurs in more serious cases of COVID-19. The study suggests that CBD may positively impact ARDS- a dangerous symptom in COVID-19. David Aronoff, MD, discusses an early study on CBD and on how to address interested patients

Early Studies Suggest CBD May Help Prevent COVID-19

Medical formulations of the compound cannabidiol — known as CBD — have shown promise as a way to prevent COVID-19.

Medical formulations of the compound cannabidiol — known as CBD — have shown promise as a way to prevent COVID-19.

What you need to know

Cannabidiol (CBD) is a cannabis compound with some medicinal properties. Unlike tetrahydrocannabinol (THC) — the main psychoactive component of cannabis — CBD does not produce a high or euphoria. The U.S. Food and Drug Administration (FDA) has approved one CBD-based medication to treat seizure disorders; other medications are in the development and testing pipeline.

Now some early studies show that CBD could help block infection with SARS-CoV-2, the virus that causes COVID-19.

What did the researchers do?

In a series of studies supported by the National Institute of General Medical Sciences, the National Institute of Allergy and Infectious Diseases, the National Cancer Institute (NCI), and the National Center for Advancing Translational Sciences, researchers tested the effects of CBD and other cannabis compounds on SARS-CoV-2. They looked at interactions between CBD and the virus in human lung cells and in mice. They also analyzed data from the National COVID Cohort Collaborative’s health records of volunteers who had been prescribed the CBD-based medication to help prevent seizures.

What did they learn?

In both the laboratory studies and the health records analyses, CBD seemed to have a protective effect against SARS-CoV-2. When the virus was introduced to human lung cells treated with CBD, it could not replicate and take hold as it usually does. Mice that were given therapeutic doses of CBD before being exposed to the virus were much less likely to develop COVID-19 than mice in the control group. And human patients who took the CBD-based medication were less likely to report a COVID-19 diagnosis than others, including people who had the same seizure disorders but had not been prescribed that medication.

Interestingly, out of more than 100 compounds in cannabis, only CBD showed this protective effect. In fact, when CBD was combined with THC, its ability to protect decreased.

What does this mean?

More research, including clinical trials, is needed, but these studies suggest that CBD might be a useful way of preventing COVID-19 in the future. The researchers caution that CBD is not a replacement for vaccination, masking, and social distancing. If anything, they write, CBD would be used along with these measures to prevent breakthrough infections.

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The researchers also emphasize that the CBD used in their studies is different from the nonmedical products consumers might be familiar with. There is no evidence that taking over-the-counter CBD products can prevent or treat COVID-19 infection.

Where can I go to learn more?

NCI provides patient-friendly information about cannabis and its compounds.

The National Center for Complementary and Integrative Health has more information about cannabis and CBD.

N3C is a partnership among several NIH Institutes and Centers that aims to use COVID-19 clinical data to answer critical research questions.

CBD For Coronavirus? New Study Adds Evidence For Cannabis As Covid-19 Treatment

CBD from cannabis could become the next COVID-19 treatment – according to new study.

As we continue to see outbreaks of the novel coronavirus surging, many are waiting and hoping for treatments to be developed that might treat, cure or prevent the potentially deadly disease. In a surprising turn of events, cannabis is on the list of potential treatments.

While researchers are exploring many different possibilities in combating COVID-19, some researchers are looking into whether cannabis or cannabis derived CBD might offer benefits for those suffering from severe forms of this infection. Interestingly, there have been several different ways researchers have suggested CBD might help, including its ability to reduce ACE2 expression and pro-inflammatory cytokine production to fight lung inflammation, and it’s potential as an antiviral . But few studies have tested these theories with actual experimentation.

Now new evidence is adding support to the theory that cannabis derived CBD may help those suffering from the severe lung inflammation that occurs in more serious cases of COVID-19. The study from researchers at Augusta University in Georgia suggests that CBD may positively impact ARDS or acute respiratory distress syndrome – a dangerous symptom in COVID-19 caused by an overactive inflammatory response. This is sometimes referred to as a ‘cytokine storm’. The authors of the study explain that “currently, other than supportive measures, there is no definitive cure for ARDS, illustrating the urgent need for creative and effective therapeutic modalities to treat this complex condition.”

But CBD may be able to help treat this dangerous symptom of COVID-19. The researchers suggest CBD may be able to help by reducing pro-inflammatory cytokine production, fighting off the storm. By reducing specific cytokines such as interleukin (IL)-6, IL-1b, and IL-17, we may be able to bring down the inflammation and thus end the respiratory distress and damage. And the results of these researchers’ experiments supported this theory.

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The research itself was performed on mice, who were first given a treatment called Poly(I:C) to artificially induce ARDS, with symptoms similar to what we see in severe COVID-19 patients. This created a cytokine storm, reduced the blood oxygen saturation by 10%, and even produced structural damages to the lungs in mice subjects. Then after the mice were experiencing the cytokine storm and coinciding respiratory distress, they were given CBD. And the results showed just how powerful CBD can be when treating ARDS. “These symptoms were totally or partially reversed and returned to the level and condition of the normal after treatment with CBD” the authors report.

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Cannabis derived CBD may help fight off severe lung inflammation caused by COVID-19

In particular, mice treated with CBD saw reduced expression of IL-6, an important marker for cytokine storms, and lowered the levels of other proinflammatory cytokines. While the Poly:(I:C) spiked inflammatory markers, “CBD treatment reversed all these inflammatory indices and partially re-established homeostasis” the authors explain. Mice treated with CBD also had increases in lymphocyte levels in their blood, which are important white blood cells for fighting off infections.

Researchers on the study say that CBD could play an immunotherapeutic role in treating severe respiratory viral infections like COVID-19, based on the present findings.

“The current data support the notion that the anti-inflammatory function of CBD may reduce cytokine storm and mitigate the effects of exaggerated inflammation” they explain. They add that “considering all potential regulatory effects of CBD as well as the vast distribution of endocannabinoid system in the body, it is plausible that CBD may be used as a therapeutic candidate in the treatment of various inflammatory conditions including COVID-19 and other virus-induced ARDS.”

More research could help us learn how cannabis and CBD can help fight the novel coronavirus

Of course, this is an early study, and more research needs to be done – particularly more research that tests this theory on actual human subjects with COVID-19 related ARDS. The authors point out that “obviously, more studies are required to expand and validate this therapeutic strategy.”

While we may have to wait for more research before this is being used as an active treatment for COVID-19, this study gives us good reason to hope that CBD might eventually be harnessed to help fight ARDS. It also adds to the chorus of researchers and cannabis advocates suggesting that we look further into cannabis and its potential to fight this deadly disease.

So, Your Patient Just Asked About CBD for COVID-19?

— David Aronoff, MD, discusses an early study on CBD and on how to address interested patients

by Emily Hutto, Associate Video Producer January 28, 2022

In this video, David Aronoff, MD, chair of the department of medicine at Indiana University School of Medicine in Indianapolis, discusses a recent study testing cannabidiol (CBD) against COVID-19 in the lab and in mice, and how to guide patients seeking treatment for COVID-19.

The following is a transcript of his remarks:

If a patient were to come to me and ask about the use of CBD oil to prevent COVID-19 or reduce the severity of it, I would say that right now, that approach is not ready for prime time. There are other, better ways that we know are safe and very effective to prevent COVID-19 and reduce the severity if someone gets ill. So wear your mask, socially distance, get vaccinated, and if you get symptomatically ill with COVID, let a healthcare professional know, because you may be eligible for things like monoclonal antibodies or new medications like Paxlovid [nirmatrelvir/ritonavir] or repurposed medicines like fluvoxamine [Luvox]. But it’s really important to engage with a licensed healthcare professional if you’re sick with COVID-19.

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These investigators thought that there may be some anti-inflammatory effects of CBD, and that might be useful to suppress some of the inflammation that can occur in patients who have COVID-19. But the investigators found a surprising result, which is that CBD and one of its active metabolites didn’t really have too much of an effect on the inflammatory response of the epithelial cells they were studying. But rather, and curiously, the CBD seemed to block the replication of the SARS CoV-2 virus in the respiratory epithelial cells.

This really led the investigators to dig deeper into trying to understand whether the effect they were seeing was specific to CBD or could be found in other compounds that may be also identified in marijuana and to try to drill down on mechanisms through which CBD could be limiting SARS CoV-2 replications in epithelial cells.

And finally, based on what they found in vitro, they wanted to know if there were any correlates of this compound being used in humans that may show some promise for reducing the risk of COVID-19 and even went as far as doing an interventional study in mice to look at the impact of CBD on reducing the severity of SARS COVID-2 infection in a mouse model.

While this study is really interesting and promising, we don’t yet have data in humans that show that we can use CBD oil in therapeutic ways to prevent COVID-19 or reduce the severity of COVID-19. And really what we need is an actual randomized placebo-controlled, double-blind study, which is now regularly being done to look at therapeutic and preventive strategies for COVID-19. Right now, the best we can say about CBD oil is that it’s a promising idea. But until we have properly controlled studies, we don’t actually know how effective or not this is in humans.

Even the human component of the study that was just published, although it was retrospective, which has its limitations, it was looking at essentially medical-grade CBD oil used in the treatment of people who have severe seizure disorders. So we really don’t know how commercially-available, easy-to-get CBD preparations might perform in protecting people from COVID-19.

Emily Hutto is an Associate Video Producer & Editor for MedPage Today. She is based in Manhattan.

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