Biomedical research studies based on animal models have been far more numerous than human clinical trials. Much of the research shows promising results for the potential use of cannabinoids in the treatment of a host of human medical conditions, including diabetes, psychiatric, neurodegenerative, and gastrointestinal disorders. In regards to pain, research conducted thus far, along with countless user reports, suggests that CBD alone may be able to help relieve both inflammatory and neuropathic pain in humans. As just one of many examples, a paper in the European Journal of Pain revealed that rats with arthritis who are treated with transdermal CBD experienced reductions in pain-related behaviors and inflammation 6 . These animal-based studies are helping to further our knowledge of cannabis’ potential medical benefits. More importantly, they are opening the door for more human-based research and clinical trials to be conducted down the line.
Note from the editor: A few years ago I had an acute back injury that I wrote about on this site. After surgery and during recovery (and a lot of physical therapy), I was determined to avoid the standard opioid medications that are often doled out for severe pain—and the side effects that come with them. I was immediately recommended CBD oil by a friend, which I was admittedly very skeptical about. But after having immediate results during periods of immense pain, I was interested in whether there was actually something to this “miracle drug.” During the first few weeks after the injury, I would use CBD several times per day, often when the pain became overwhelming or would keep me awake at night. To be honest, I was surprised when it worked. Virginia was even more of a naysayer than me, and with her career background in medical research, she began a deep dive into materials and studies that substantiate or disprove claims about CBD products. In the end, she put together this thorough article on the subject. It’s unlike most of the content we publish here, but I thought it was absolutely worth sharing. -Logan Watts
Some science also suggests that finding the therapeutic range of a full-spectrum CBD product (one with a range of cannabinoids in addition to CBD as well as terpenes) may be easier when compared to a CBD-isolate. 17
Dangers specifically associated with vaping have been making big news of late. In light of the recent surge in morbidity and mortality related to vaping, The Centers for Disease Control and Prevention (CDC) is recommending that people should not use THC-containing e-cigarette or vaping products, particularly those from informal sources like “friends, or family, or in-person or online dealers.” They have also added that “the only way to assure that you are not at risk while the investigation continues is to consider refraining from use of all e-cigarette, or vaping products.” 13
While the FDA considers CBD a drug, they have, thus far, treated it more like a supplement in terms of regulation. The FDA has yet to force any testing standards on manufacturers of CBD products. They are aware that these CBD products have not undergone rigorous clinical trials, yet products remain available to consumers. What the FDA has done, however, is crack down on manufacturers for making unsubstantiated claims about their products. The FDA went a step further in its admonition to CBD product manufacturer Curaleaf, Inc., stating in its warning letter dated 22 July, 2019, that a number of their products are unapproved and misbranded “new drugs” and that “there are many unanswered questions about the science, safety, effectiveness, and quality of unapproved products containing CBD.” 12 Curaleaf, Inc. was ordered to correct stated violations or face legal action without further notice.
Bicycles have always been our hobby, our passion and our job. For years we worked hard in the mountain bike business.
After work we would ride our city bikes to the local cafes and restaurants and talk about our dream of creating a new, special bike brand. One day, after stumbling across a bunch of beautiful old bike parts in a friends attic and realising just how little care and attention to detail can be found in today’s city bikes, we decided that it was time to make our dream a reality. It was then that Creme was born. The journey was long but today, when we see our bicycles on the streets and the happy faces of their owners, we know it was worth it. Creme bicycles are designed and hand built in Europe. Each one is a tribute to the love for materials, details and craftsmanship. We hope that you will see these values in our bicycles and that they will bring you the same joy as they have given us.
A recent study has also shown that CBD given for seizures related to epilepsy (a condition which CBD has been FDA-approved for) is much better absorbed when ingested along with high-fat food. A group in the study that was assigned to eat a high-fat meal before taking CBD had a 14 times better absorption of it on average compared to those who took CBD without food.
Unfortunately, research on other uses of CBD, besides epilepsy, is in its early years and there is no standard dose that delivers a consistent effect for all people. CBD products are also considered supplements so, they are not well regulated. In general, it’s best to start with a very low dose and gradually increase it based on the effects you experience.
Athletes from a variety of different sports are paying increasing attention to a new supplement called cannabidiol or CBD. It’s promising better recovery, improved pain management reduction during inflammation, and better sleep. That almost sounds too good to be true. So, let’s take a closer look at all you need to know about CBD as a cyclist.
How much should you use
The World Anti-Doping Agency removed CBD from the list of prohibited substances, both in or out of competition, at the beginning of 2018. So, CBD is legal for athletes. Just keep in mind that it’s only CBD that has been cleared, THC is still prohibited in competition. As an example, triathlete Lauren Goss was handed a 6-month ban by the United States Anti-Doping Agency for THC levels in her blood. She blamed it on a CBD cream she was using out of competition for an injury. So, be extra careful especially with full-spectrum CBD products as they can contain some amount of THC.
There are CBD capsules, pills, and oils on the market, so you will be able to find a variety of creams and lotions, recovery drinks, edibles, drops, and tinctures with the substance. Capsules, oil, and edibles have to be digested so they take longer to take effect. Topical creams are generally quicker than edibles, sublingual drops are even quicker than that and inhalation via vaping is the fastest method.
Cannabidiol (CBD) is a phytocannabinoid found naturally in the cannabis plant but it is not psychoactive like its well-known cousin tetrahydrocannabinol (THC). Cannabinoids are substances that already exist in the human body. We all have what is called the endocannabinoid system (ECS) that modulates the activity of neurons to maintain homeostasis. As a cyclist, you apply greater stress to your body than your ECS can handle, which leads to pain and inflammation. Supplementing with CBD may help the overloaded system get your neurotransmitters back under control.
It’s also worth noting that CBD is available as “full-spectrum” or “isolate”. Full-spectrum CBD products contain CBD and other compounds found in the original plant, which could include small amounts of THC. Products that contain CBD isolate should only contain CBD.