One 2006 study published in the journal Autoimmunity showed that CBD reduced the incidence of diabetes in animal models. To date, however, very little research has specifically covered CBD’s potential in human diabetes treatment or interactions with metformin. Only one study, conducted by the American Diabetes Association and published in 2016 in the journal Diabetes Care, has examined the efficacy of CBD in patients with type 2 diabetes and found it had no significant impact on glucose levels.
These drug classifications include a large percentage of existing prescriptions, such as benzodiazepines, antihistamines, haloperidol, antiretrovirals, statins, cyclosporine, sildenafil, warfarin, and other drugs metabolized by CYP3A4 and CYP2D6.
Metformin is a medication prescribed to adults with type 2 diabetes to help control blood sugar levels. Side effects of metformin include low blood sugar, nausea, diarrhea, vomiting, and muscle pain.
Should I take CBD with Xanax?
No studies have examined potential interactions between CBD and metoprolol. However, some placebo-controlled research conducted on healthy people at the University of Nottingham in England and published in 2017 in the journal JCI Insight has linked CBD with decreased blood pressure when taken on its own. For patients taking metoprolol, however, the combination with CBD could potentially have negative impacts on blood pressure.
Further, a 1993 study conducted by pharmacology researchers at the University of California, San Francisco, and published in the journal Biochemical Pharmacology, discovered that CBD, much like grapefruit, disrupts the normal function of cytochrome P450 enzymes in mice. The study postulated that while the blockage could allow patients to take lower doses of their prescriptions, it could also cause a toxic buildup of chemicals in the body. Since this study’s publication, several scientific and medical journals have published evidence of the grapefruit-like effects of CBD in humans.
Potentially, CBD can increase the duration and strength of ibuprofen, thereby increasing the risk of adverse side effects. No human studies to date examine CBD’s interaction with NSAIDs specifically. Still, two studies conducted on animal models in 2006 and 2008 and published respectively in the journals, Pain and Pharmacology, suggest that other cannabinoids may work synergistically with NSAIDs like ibuprofen to reduce pain.
Patients using Plavix or clopidogrel should consult their physicians as to whether they should use CBD.
Ibuprofen specifically targets the COX-1 and COX-2 enzymes by decreasing their activity. These two enzymes trigger inflammation and fever  .
How Ibuprofen Works
On the flip side, you have cannabidiol, a promising compound from the cannabis plant. CBD, as it’s most commonly known, has been a subject of study for several conditions, including pain. But, unlike ibuprofen, it does not have approval from medical experts yet.
As for CBD, it is extracted from the hemp plant with the help of a solvent like ethanol or carbon dioxide. The cannabidiol is then transformed into oil, topical, or capsule gel form for consumption.
On the one hand, you have a fast-acting synthetic drug with known side effects and health risks. On the other, you have an organic substance that’s perceived to have its own benefits—without the risks  . Looking at it on paper, combining the two isn’t such a bad idea.