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can cbd cream side effects

Generally speaking, CBD is considered a safe substance when applied topically or taken orally. There are, however, some potential side effects to keep in mind when using this substance, the majority of which are mild.

It’s important to point out that CBD is not regulated by the FDA and therefore dosages might not be accurate. It’s also difficult to know what an appropriate dose is the first time you try a new product.

Common Side Effects of CBD

Also known as “cotton mouth,” CBD can potentially cause your mouth and eyes to feel very dry, notes Dr. Brent A. Bauer via Mayo Clinic. Though this side effect is more likely to occur with THC, it can happen with CBD, as well.

In some cases, those who ingest CBD supplements might experience nausea, says Dr. Matharu-Daley. This depends on how sensitive the person is to CBD, as well as the amount they ingest.

Because CBD supplements come in so many different forms—such as oils, gummies, tinctures, and vapors—the amount that’s actually absorbed can vary drastically. This, combined with each person, will ultimately affect which (if any) CBD side effects you might experience.

Although products made with CBD are becoming more widespread and popular among consumers, there is still a lot of misinformation circulating about this agent of wellness. Thus, it is important to get to know CBD properly so that you can separate fact from fiction.

Cannabis acts on the endocannabinoid system, a unique system of endogenous receptors, endocannabinoids and metabolic enzymes that is spread throughout every human’s body. The system plays a mediating role in vital functions and processes like nausea, inflammation, pain , memory, sleep, appetite, immune function, motor control, mood, reproduction and fertility, pleasure and temperature regulation, to name but a few examples. Around our bodies, we have cannabinoid receptors, which come in two types: CB1 and CB2 receptors. These specific receptors are affected when we take cannabinoids like CBD or THC, and it is through our receptors that CBD can exert its effects on us.


If you are suffering from diarrhoea after your CBD consumption, it is also possible that some of the product’s ingredients may be causing diarrhoea or contributing to gastrointestinal distress. MCT oil is frequently used as carrier oils in commercial CBD products, and has been known to cause loose stool and diarrhoea in consumers who are not used to taking it. Of course, do not continue to take your CBD product if you are experiencing this reaction, or lower your dose significantly. As always, consult your doctor if you do have concerns.

Unfortunately, there is not much reliable information out there regarding the potential side effects of topically-applied CBD. This could be taken as a positive, as it is indicative of few reports of adverse reactions when using CBD in this format. However, side effects are by no means an impossibility, so if you do experience an allergic reaction to a CBD topical, do not continue to use it and seek medical attention if necessary.

According to the literature, CBD can tackle nausea and vomiting by manipulating the ECS. In 2011, Parker and her team of researchers postulated that “cannabinoids, including CBD, may be effective clinically for treating both nausea and vomiting produced by chemotherapy or other therapeutic treatments”.

CBD oil should be avoided during pregnancy and breastfeeding. A 2018 study from the American Academy of Pediatrics warned women to avoid marijuana during pregnancy due to the potential risks to a baby’s development. Although it is unclear how CBD contributes, CBD is known to pass through the placental barrier.

As CBD grows in popularity, so does the research on it but there are currently few clinical studies on the effects of CBD oil. As such, some of these claims are better supported by studies than others.

According to the investigators, men provided 300 mg of CBD exhibited less anxiety than those given a placebo. Interestingly, those provided 100 mg or 600 mg of CBD oil did not.


In all but a few studies, lower doses of CBD (10 milligrams per kilogram, mg/kg, or less) improved some symptoms of anxiety. Higher doses (100 mg/kg or more) exhibited virtually no effect.

According to a 2012 study in the Journal of Experimental Medicine, rats injected with inflammatory chemicals in their hind feet experienced less inflammation and neuropathic pain when treated with an oral dose and spinal injection of CBD.  

CBD oil can interact with certain medications, including some drugs used to treat epilepsy. CBD inhibits an enzyme called cytochrome P450 (CYP450), which metabolizes certain drugs. By interfering with CYP450, CBD may either increase the toxicity or decrease the effectiveness of these drugs.

CBD oil may reduce the risk of heart disease by alleviating hypertension (high blood pressure) in certain people, suggests a 2017 study in JCI Insight.