That said, inhaling cannabis guarantees increased bioavailability because molecules are transported by vapor particles directly to the alveoli in the lungs. This allows cannabinoids to rapidly enter the bloodstream without being metabolized by the liver.
Oral administration lasts longer than smoking, eliminating the need for frequent dosing. Oral methods also avoid irritation to the airways and the risk of malignancies associated with smoking or vaping.
CBD and THC oils resist absorption into the bloodstream because the human body is up to 60% water . Basic science—and salad dressing—dictates that oil and water do not mix, and the same is true for cannabis oil and the human body.
Which methods of cannabis consumption optimize bioavailability?
For those who smoke or vape, bioavailability can be enhanced by minimizing sidestream loss and increasing the number of puffs. “Using a desktop or handheld vaporizer with flower will eliminate sidestream losses,” Frye advises. If you think you get more bang for your buck by holding your breath, think again. “There is no evidence supporting holding one’s breath for more than 10 secs,” says Frye.
It’s critical to get clued up about bioavailability in order to maximize the medicinal potency of cannabis. The more bioavailable your cannabis, the lower the quantity of the plant you need to reap its benefits.
One method that boosts the absorption of edibles is to combine cannabis product with fats. Frye recommends combining edibles or tinctures with healthy fats such as guacamole, hummus, or dark chocolate. If you’re feeling less virtuous, however, ice cream works as a treat. The same goes for alcohol-based tinctures.
Bioavailability refers to the degree and rate at which a substance is absorbed into your bloodstream to be used where needed. Physiological processes and consumption methods can affect cannabis absorption, rendering its effects somewhat hit-and-miss.
In contrast, most scientific studies, including the research mentioned earlier, still rate edibles somewhere in the 4–20% bioavailability range. This low bioavailability is believed to be mostly accurate, until the day an edible gets the better of you. 10mg of THC per serving is considered an effective dose by state law in California.
Cannabis edibles, whether infused with CBD or THC, have always been hit or miss for consumers. Sometimes, a single space cake can get you fantastically high. On other occasions, a whole batch of cannabis cookies seems to have little effect.
Sublingual CBD oil tinctures are the health and wellness trend of 2018, and for good reason. Although the conclusive research to silence the critics has yet to be performed, millions of people around the world are already convinced. A few drops of CBD oil under the tongue seems to boost bioavailability significantly.
BIOAVAILABILITY OF EDIBLES
That being said, a 2005 study  called “Pharmacokinetics of cannabinoids” found smoked THC to have about 30% average bioavailability. More interesting still, they discovered this: “With a 3.55% THC cigarette, a peak plasma level of 152±86.3ng/ml occurred approximately 10 min after inhalation”. Despite the relatively low potency of the joints used in the study, for the daily joint smoker, 10 minutes to get high sounds about right.
Bioavailability is defined as follows: “The degree to which a drug or other substance becomes available to the target tissue after administration”—The American Heritage Medical Dictionary.
Whether you consume cannabis and/or hemp-based products for medicinal or recreational purposes, you need to know about bioavailability. How high you can get from THC and how much CBD can heal all hinges on bioavailability.
An intravenous dose is considered 100% bioavailable. This is because it is administered directly to the bloodstream. In ordinary decent stoner terms, this means bioavailability refers to the percentage of a dose actually absorbed by the body in comparison to an injected dose.
Although it is confusing, now that we have the basics of administering cannabinoids, let’s look at the science behind today’s applications to improve their water solubility.
The simple answer is because they can. The marketing of unregulated products like CBD “allows” companies to print what they want to believe or what they want you to believe. This is simply the nature of an unregulated industry, and unfortunately the hemp CBD industry is overflowing with overzealous assertions and outright misinformation when it comes to water solubility and bioavailability claims.
Firstly, we do the science and get the answers before we make claims. LifePatent filed patents in 2017 for water solubility and bioavailability of cannabinoids. We’ve still yet to make a claim of any kind other than the discovery of “nature’s delivery method” for cannabinoids. Our technology has been in testing for over a year. Once all the evidence is in and verified we will speak.
Making water soluble CBD: How it works
This article will help address the different methods used to make cannabinoids bioavailable. We’ll also look at CBD industry claims around water soluble CBD.
You might be surprised to find that, in reality, transdermal delivery of cannabinoids is only a theory, at least for now, but clinical tests are underway. Eventually, science will prevail as topical CBD products proliferate and inquiring minds prioritize this as an area of study. However, testing the transfer of a lipophilic molecule into water-based skin can’t truly be done without complicated scientific practices which are currently rare in the hemp industry. There is only one company that I am aware of (CV Sciences) who has created a transdermal delivery method with any strong science behind it and who was recently granted a patent for this invention.
In this video, we compared bioavailability for the most popular methods of taking this supplement.
Why, then, does the CBD industry continue to tout claims of 100% bioavailability of cannabinoids, or other inflated claims about bioavailability?