Best CBD Oil For Seizures


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CBD oil can be a safe and effective natural way to help control seizures and epilepsy. Best CBD Oil for Seizures & Epilepsy in 2022 According to the Michigan Epilepsy Foundation, 1% of Americans suffer from some form of epilepsy — a recurring neurological disorder known for Epidiolex contains cannabidiol (CBD) from the marijuana plant. It is approved to treat Lennox-Gastaut syndrome and Dravet syndrome. Learn about safety and more.

Best CBD Oil for Seizures and Epilepsy: Brand Reviews and Ratings for 2022

Epilepsy and seizures are difficult for anyone to go through and can be even tougher to control. While some people only use prescription medication to manage their seizures, others are finding success in supplementing with CBD oil. If you’ve been wanting to try CBD oil for your seizures and epilepsy but aren’t sure where to begin, then our guide to the best CBD oils for seizures and epilepsy will guide you in the right direction. Additionally, we’ll also talk about the latest research on CBD and epilepsy.

Top 15 CBD Oil Brands for Epilepsy and Seizures in 2022

CBDPure — Organic and Pure

cbdMD — Large Athletic Following

Populum — Clean and Premium CBD

Premium Jane — Wide Range of Products

Hemp Bombs — Extensive Product Line

How We Came Up with the Brands of CBD Oil for Seizures and Epilepsy

When we began to compile our list of brands for the best CBD oil for seizures and epilepsy, we made it a point to include some of the most reputable brands in the industry. We didn’t bother looking at cheaper, less reputable brands because oftentimes, these brands cut corners in the creation of their products. Sadly, cheaper brands often have products that are loaded with harmful solvents, pesticides, herbicides, and other chemicals. Moreover, these types of CBD oils are also less potent and effective. Before we drew up our list of brands, we came up with a strict set of guidelines to follow. As we were selecting our top 15 brands, we examined each and every one for:

  • Potency of the CBD oil
  • Where the hemp was sourced from
  • If the brand strongly adhered to FDA guidelines
  • The variety of oil the brand sells: full-spectrum, broad spectrum, or CBD isolate
  • The THC levels in the oil
  • The results of third-party lab reports
  • Are product instructions thorough and easy to understand
  • Overall reputation of the brand

After we closely inspected and researched each of our brands, we were able to cut the list down to the top 15 brands that you’ll read about below. These top brands had some of the highest quality CBD oils on the market that was also potent and priced affordably.

15 Best CBD Oils for Epilepsy and Seizures of 2022

#1 FAB CBD — Most Potent

Ever since the brand burst onto the scene in 2017, FAB CBD has been making some of the cleanest, most potent, and most pure CBD products in the industry. Thanks to their years of experience in the health and wellness arena, the team at FAB CBD has come up with excellent formulations for their well-loved product line that includes full-spectrum CBD oils, CBD+CBG Oil, “Anytime” and “Nighttime” CBD gummies, Topical CBD Cream, Full Spectrum CBD Body Salve, Calm & Cool Crunchy CBD Dog Treats, and CBD-free Vegan Green Superfoods.


  • Hemp Source — Organically grown hemp from Colorado
  • CBD Potency and Type — Clean and potent full-spectrum CBD oils in an array of strengths and flavors
  • Additional Ingredients — MCT oil, flavoring from natural sources, and beneficial terpenes
  • Extraction Process — Uses clean, industry-preferred CO2 extraction method
  • Third-Party Lab Reports — ProVerde Lab reports are available via the FAB CBD website

About the CBD Oil

Full-spectrum oils in strengths of 300mg, 600mg, 1200mg, and 2400 mg of CBD, and in smooth, vibrant, palate-pleasing flavors like vanilla, citrus, mint, berry, and natural.

What We Liked

We liked that FAB CBD creates clean and potent full-spectrum CBD oils in a wide range of strengths and in flavors that most everyone enjoys. We also like that the brand is extremely transparent and customer-service-oriented.

What We Disliked

The one aspect about FAB CBD that we disliked was the fact that the brand does not currently offer international shipping.

#2 Nuleaf Naturals — Best Organic

NuLeaf Naturals goes all out to make high-quality, potent, and affordable CBD products. Since 2014, the brand has been making clean full-spectrum hemp products that are free from additives and dangerous chemicals. NuLeaf Naturals has the distinction of being one of the first CBD brands to be GMP-certified (Good Manufacturing Practices-certified) and ISO-compliant (International Organization for Standardization-compliant).


  • Hemp Source — Organically grown hemp from licensed farms in Colorado
  • CBD Potency and Type — Full-spectrum CBD oils in an array of strengths
  • Additional Ingredients — Organic Virgin Hemp Seed Oil, beneficial terpenes
  • Extraction Process — CO2 extraction process
  • Third-Party Lab Reports — The brand uses an independent third-party lab to routinely test all of its products

About the CBD Oil

NuLeaf Naturals creates unflavored full-spectrum CBD oils in strengths of 300mg, 900mg, 1800mg, 3000mg, and 6000mg.

What We Liked

We liked that NuLeaf Naturals is a strong, transparent brand that offers customers clean and potent full-spectrum CBD oils.

What We Disliked

We disliked that NuLeaf Naturals does not offer any flavor options for its full-spectrum CBD oils.

#3 Green Roads — Interesting Selection

In 2013, Laura Fuentes, a licensed compounding pharmacist, set out to help her dear friend, Arby, with his health issues. It was Arby’s belief in CBD that led Fuentes to begin formulating CBD products. Once they saw the success of the formulations, Arby and Laura decided to bring the creations to more people. It was at that time that they founded Green Roads as a means to help friends and families live their healthiest lives. As more people learned about Laura’s products, the company began to grow by leaps and bounds.


  • Hemp Source — The brand has a partnership with many farms throughout the United States
  • CBD Potency and Type — Full-spectrum, broad spectrum, and CBD isolate products in a variety of strengths and flavors
  • Additional Ingredients — Glycerine, MCT oil, natural flavorings, sunflower lecithin, sunflower oil, hemp seed oil
  • Extraction Process — CO2 extraction method
  • Third-Party Lab Reports — Green Roads uses an independent third-party lab, Kaycha Labs, to test every product for herbicides, pesticides, heavy metals, and more

About the CBD Oil

Green Roads offers full-spectrum and broad-spectrum CBD oils in strengths of 300mg, 750mg, and 1500mg in flavors like Apple Kiwi Bliss, Mint Breeze, and unflavored. The brand also makes a 25mg strength single-serving Daily Dose CBD oil and Sweet Sleep CBD Nightly Dose. The Sweet Sleep CBD Oil is also available in a bottled strength of 750mg.

What We Liked

We liked that the brand had so many options when it came to CBD products. We also liked the strong selection of CBD oil strengths.

What We Disliked

We disliked that some of the flavor options for the CBD oils were limited. We also disliked that the website was a little tough to navigate.

#4 MedTerra — Top Quality

MedTerra was founded by a band of passionate CBD lovers. The group of friends held a staunch belief in the healing power of the cannabis plant. Today, everyone at MedTerra still goes above and beyond to make sure that CBD is affordable and available to everyone. The brand is involved from seed to sale because MedTerra aims to be accountable for what it creates. MedTerra employs a team of experts that has knowledge in vegetable genetics, quality control, food-grade compound extraction, and best hemp farming practices.


  • Hemp Source — Kentucky grown, non-GMO hemp source
  • CBD Potency and Type — Full-spectrum CBD oils in a large range of potencies
  • Additional Ingredients — MCT oil, natural flavors, stevia extract
  • Extraction Process — CO2 extraction method
  • Third-Party Lab Reports — All products are tested by a third-party lab

About the CBD Oil

MedTerra offers full-spectrum CBD oil Hemp Drops in strengths of 750mg, 1500mg, 3000mg and 6000mg in flavors of Citrus and Chocolate Mint.

What We Liked

We liked the many varieties of CBD oil strengths that the brand has to offer its customers. We also liked that MedTerra ships internationally and offers rewards and assistance programs.

What We Disliked

We disliked the fact that MedTerra’s flavor options were limited.

#5 CBDistillery — Large Selection

CBDistillery was founded in 2016 with the mission to create top-quality, fairly-priced CBD products for everyone. The brand’s ultimate vision is to bring CBD to the world. The team at CBDistillery values accountability, teamwork, respect, a can-do attitude, a drive to succeed, and an ability to enjoy your work. A group of Colorado natives founded the brand with the public’s best interest in mind. Because the brand’s founders saw a CBD market that was saturated with inferior, overpriced products, they sought to create a product line that was high-quality, fairly priced, and that was made from clean, organic hemp grown in the United States. Additionally, they also wanted to educate the public about CBD and other alternative methods of wellness.


  • Hemp Source — non-GMO industrial hemp grown in Colorado
  • CBD Potency and Type — Full-spectrum, broad spectrum, and CBD isolate product options
  • Additional Ingredients — Fractionated coconut oil, natural flavors, natural terpenes
  • Extraction Process — Organic ethanol and CO2 extraction
  • Third-Party Lab Reports — Each product is lab tested for potency and quality, and QR codes are made available for customers to access third-party lab reports

About the CBD Oil

CBDistillery offers full-spectrum, broad-spectrum, and CBD isolate oils in strengths of 500mg, 1000mg, 2500mg, and 5000mg in natural or mango flavors.

What We Liked

We liked that CBDistillery offers full-spectrum, broad-spectrum, and CBD isolate products that are vegan and gluten-free.

What We Disliked

We disliked that there were only natural and mango flavor options for CBDistillery’s CBD oils. The brand only currently ships within the United States.

#6 Joy Organics — Strong Variety

Joy Organics was founded as a means to create top-notch CBD products through innovation and excellence. Moreover, CEO and Co-Founder Joy Smith started Joy Organics after struggling with her own health issues. Smith tried many CBD brands with little success before deciding to start her own company. To this day, everyone at Joy Organics works tirelessly to develop new formulas while improving existing ones.


  • Hemp Source — American farms that are Farm Bill-compliant
  • CBD Potency and Type — Broad spectrum and full-spectrum CBD products in an array of potencies
  • Additional Ingredients — Organic extra-virgin olive oil, organic natural flavorings
  • Extraction Process — Supercritical CO2 extraction method
  • Third-Party Lab Reports — All products are tested by an independent third-party lab and those results are then posted on the brand’s website

About the CBD Oil

Joy Organics creates both broad-spectrum and full-spectrum CBD oils in flavors like Natural, Tranquil Mint, Orange Bliss, Fresh Lime, Tropical Sunrise, and Summer Lemon and in strengths of 450mg, 900mg, 1350mg, and 2250mg.

What We Liked

We liked that Joy Organics creates its products using organic farming methods and is completely transparent with customers. The brand also offers free shipping on all orders.

What We Disliked

We disliked the fact that the brand does not offer international shipping.

#7 Seabedee — Best Flavors

Seabedee seeks to help people heal in natural ways through the use of high-grade CBD products. The brand’s main mission is to produce top-quality CND products that customers love and trust. Seabedee offers both full-spectrum and broad-spectrum CBD oils, along with special oils that are targeted towards various health conditions. For example, customers can select from oils that help to treat sleep issues, anxiety, and inflammation.


  • Hemp Source — The brand sources its organic hemp from farms in Oregon and Kentucky
  • CBD Potency and Type — Full-Spectrum and Extra Strength Full-Spectrum oils in a solid range of strengths and flavors
  • Additional Ingredients — Terpenes, organic MCT oil, natural flavors
  • Extraction Process — CO2 extraction process
  • Third-Party Lab Reports — All products are tested by an independent third-party lab

About the CBD Oil

Full-Spectrum CBD oils designed to target specific health issues including Extra Strength Full-Spectrum CBD Oil in 1500mg or 3000mg strengths in vanilla or peppermint flavors, unflavored CBD Calming Blend in 500mg strength, unflavored CBD Recover Blend in 500mg strength, and unflavored Sleep Blend in 500mg strength.

What We Liked

We liked that Seabedee has general full-spectrum oils as well as extra strength full-spectrum oils and specialty CBD oils geared towards specific health issues like sleep, inflammation, and stress.

What We Disliked

We disliked that there was only one potency option for the brand’s condition-specific CBD oil blends.

#8 Lazarus Naturals — Clean and Effective

Since 2014, Lazarus Naturals has prided itself on creating clean, affordable CBD products. The founders of the brand have a staunch belief that everyone should be able to buy CBD products regardless of their finances. Lazarus Naturals also works hard to help underserved communities through its partnership with non-profit organizations and donations to causes like The Epilepsy Foundation. The brand’s main headquarters are located in Portland, Oregon.


  • Hemp Source — Organic hemp sourced from Central Oregon
  • CBD Potency and Type — The brand creates full-spectrum CBD oils in an array of potent strengths and in interesting and delicious flavors
  • Additional Ingredients — Organic coconut MCT oil, natural flavor, terpenes
  • Extraction Process — Ethanol extraction process
  • Third-Party Lab Reports — All of Lazarus Naturals’ products are tested by Columbia Laboratories, a third-party laboratory

About the CBD Oil

The brand crafts full-spectrum CBD oils in strengths of 600mg, 750mg, 1200mg, 1500mg, 2400mg, 3000mg, 6000mg, and in interesting flavors of Chai Tea Latte, Classic Flavor, Chocolate Mint, French Vanilla Mocha, Yuzu, Blood Orange, Flavorless, and Wintermint.

What We Liked

We liked that Lazarus Naturals has a wide array of CBD oil potencies. We also liked the fact that the flavor options were both unusual and interesting.

What We Disliked

We disliked the fact that the brand only ships its products to select countries. Also, users report that some of the flavor options are not pleasant. For example, some customers dislike the overwhelming molasses flavor of the French Vanilla option.

#9 Cheef Botanicals — Education Focused

Cheef Botanicals has a goal to educate the world about the healing power of the hemp plant. The brand was founded by a group of cannabis lovers with over 25 years of experience in the organic food industry. Cheef Botanicals’ founders started the brand because they all agreed that there was a lack of health-centered, plant-based cannabis products in California. All of the brand’s products are vegan, organic, gluten-free, cruelty-free, non-GMO, and dairy-free.


  • Hemp Source — The brand has a partnership with hemp farms in Colorado
  • CBD Potency and Type — Cheef Botanicals has a limited variety of full-spectrum oils that only come in natural flavor
  • Additional Ingredients — Hemp seed oil and CBD oil
  • Extraction Process — CO2 extraction process
  • Third-Party Lab Reports — All third-party lab reports are available on the brand’s website

About the CBD Oil

Cheef Botanicals makes a full-spectrum CBD oil in natural flavor in 300mg, 600mg, 1200mg, and 3000mg strengths, and full-spectrum Hemp CBD Oil Drops in strengths of 300mg. 1200mg, and 3000mg in natural flavor.

What We Liked

We like that the brand puts forth clean and potent full-spectrum oils.

What We Disliked

We dislike that the CBD oil flavor and options at Cheef Botanicals are limited.

#10 CBDPure — Organic and Pure

CBDPure first made its way into the industry in 2016. The brand has a mission to make high-quality CBD products that are routinely tested by an independent third-party lab and that come with a 90-day, money-back guarantee. CBDPure makes full-spectrum oils that are effective and free from harmful chemicals. The brand’s hemp is routinely tested for heavy metals, pesticides, and other dangerous chemicals. While no flavor options are offered, CBDPure still has a solid selection of oil strengths to choose from.


  • Hemp Source — The brand’s hemp is both organic and non-GMO and is grown and harvested in Colorado and Washington
  • CBD Potency and Type — Full-Spectrum CBD oils with no flavor options
  • Additional Ingredients — Natural ingredients, terpenes, and cannabinoids
  • Extraction Process — CO2 extraction process
  • Third-Party Lab Reports — All products are tested by an independent lab

About the CBD Oil

Unflavored full-spectrum CBD oils in strengths of 300mg, 600mg, and 1000mg.

What We Liked

We liked that CBDPure offers customers many different CBD oil strengths to choose from.

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What We Disliked

We disliked the fact that the brand’s CBD oils do not come in any flavor options.

#11 PlusCBD — Unique Products

PlusCBD has been working to better the health and wellness of its customers since 2012. Everyone associated with the brand believes in the healing power of hemp, in being transparent and open with customers, and in making effective and affordable CBD products. The brand’s founders believe that mental and physical health are of utmost importance and seek to craft unique wellness products that support the physical and mental health of their customers. PlusCBD sticks to its core values which include integrity, trust, customer service, and leading the industry with science- and nature-backed products.


  • Hemp Source — European Agricultural hemp grown from EU-certified seeds
  • CBD Potency and Type — Full-spectrum CBD oils in a nice variety of strengths and flavors
  • Additional Ingredients — Extra virgin olive oil, natural sweeteners, natural flavors
  • Extraction Process — CO2 extraction process
  • Third-Party Lab Reports — Third-party lab testing of every product

About the CBD Oil

Full-spectrum CBD Drops in Dark Chocolate Mint, Lemon Ginger, unflavored, Peppermint, and Unsweetened Original flavors in 250mg, 500mg, 750mg, 1500mg, and 3000mg potencies.

What We Liked

We liked that the brand has a solid line of full-spectrum oils that come in a nice array of flavors and potencies.

What We Disliked

We disliked that PlusCBD doesn’t offer detailed information on where their hemp plant is sourced over in Europe.

#12 cbdMD — Large Athletic Following

cbdMD has a large line of products that customers can choose from. Some of the brand’s products include bath bombs, topicals, sprays, CBD oil tinctures, gummies, CBD oil for pets, and more. cbdMD prides itself on being highly transparent about its CBD creation methods and holds the loyalty and trust of its customers in high esteem. The brand believes that CBD should be affordable to everyone, and as such, keeps its product prices competitive and affordable.


  • Hemp Source — Hemp that’s sourced from farms throughout the United States
  • CBD Potency and Type — Broad spectrum oil in a large line of potencies and flavors
  • Additional Ingredients — MCT oil, terpenes, and natural flavor
  • Extraction Process — CO2 extraction method
  • Third-Party Lab Reports — All products are tested by an independent lab that’s also ISO-certified

About the CBD Oil

Broad spectrum oil in strengths of 300mg, 750mg, 1000mg, 1500mg, 3000mg, 5000mg, and 7500mg, and in flavors like natural, berry, orange, and mint.

What We Liked

We liked that the brand has so much product variety to offer customers.

What We Disliked

We disliked the fact that the brand’s large product variety can be overwhelming to new CBD users.

#13 Populum — Clean and Premium CBD

Populum makes clean and potent CBD oil in an ethical and honest manner. The brand creates all of its products in the USA. All products are affordable and effective and are made using a special formulation of full-spectrum hemp extracts. All of Populum’s products are vegan, non-GMO, and gluten-free. Since the brand made its way into the industry in 2016, customers have always valued the quality of its products and its transparency and consistency.


  • Hemp Source — Non-GMO, Colorado-grown hemp
  • CBD Potency and Type — Full-spectrum Hemp CBD Oil that comes in a nice line of potencies and in only one flavor option
  • Additional Ingredients — Grapeseed oil, MCT oil, hemp seed oil, natural flavors, terpenes, cold pressed orange oil
  • Extraction Process — Ethanol extraction process
  • Third-Party Lab Reports — The brand tests each product three times with a third-party lab

About the CBD Oil

Full-spectrum Hemp CBD Oil in 250mg, 500mg, 1000mg, and 2000mg strengths that come in a natural orange flavor.

What We Liked

We like that Populum triple tests all of its products with a third-party lab. We also liked that the brand offers free shipping on all orders.

What We Disliked

We disliked the fact that the brand only offers its oils in a natural orange flavor.

#14 Premium Jane — Wide Range of Products

Premium Jane is located in Scottsdale, Arizona. The brand’s founders and its staff have worked for many years to help educate customers about CBD’s many benefits. The brand makes a unique line of affordable, organic products that customers stand by. Premium Jane uses knowledge, passion, and top-notch materials to make all of its products. The brand employs agricultural experts and farmers to ensure that all of its hemp is pure, and chemists, biologists, and marketing developers to help keep its product line evolving.


  • Hemp Source — Hemp that’s grown and regulated in Kentucky
  • CBD Potency and Type — Full-spectrum CBD tinctures in three potencies and a wide array of natural flavors
  • Additional Ingredients — Fractionated coconut oil, natural flavors, terpenes
  • Extraction Process — CO2 extraction process
  • Third-Party Lab Reports — All products are tested by a third-party lab

About the CBD Oil

Full-spectrum CBD tinctures in 300mg, 600mg, and 1000mg strengths and in flavors like Natural, Mint Chocolate, Lemon Lime, and Peach Nectar.

What We Liked

We liked that Premium Jane has so many flavor options for its CBD oils.

What We Disliked

We disliked that the brand had limited CBD oil potencies.

#15 Hemp Bombs — Extensive Product Line

Hemp Bombs, located in Tampa, Florida, was founded in 2016. The brand’s mission is to make high-quality CBD products from the best industrial hemp. Hemp Bombs crafts broad-spectrum and CBD isolate products like CBD oils, capsules, topical products, and gummies. In creating its line of products, the brand wanted to ensure that its customers had a large variety to choose from.


  • Hemp Source — The brand sources its organic hemp from European farms
  • CBD Potency and Type — Full-spectrum CBD oils in a solid array of potencies that come in a fun and delicious line of flavor options
  • Additional Ingredients — MCT oil, grapeseed oil, natural flavors
  • Extraction Process — CO2 extraction process
  • Third-Party Lab Reports — Each product is tested by a third-party lab

About the CBD Oil

Full-spectrum CBD oils in 300mg, 750mg, 1500mg, 3000mg, and 5000mg potencies that come in Acai Berry, Chocolate Mint, Orange Creamsicle, Peppermint, Watermelon, and Natural Hemp flavors.

What We Liked

We liked that Hemp Bombs’ CBD oils come in many strengths and flavors.

What We Disliked

We disliked that the brand does not have any full-spectrum CBD options.

What Research Says About CBD and Epilepsy

When the electrical activity in the brain changes, seizures are the result. According to scientists, there are a host of seizure types as well as potential causes. Some of the things that can cause seizures include:

  • Infections in the brain
  • Epilepsy
  • Severe lack of sleep
  • Traumatic brain injuries
  • Imbalances in electrolytes
  • Drug overdoses

CBD, or cannabidiol, one of the main chemical compounds found in the hemp and marijuana plants, has been shown to help people manage chronic pain, lower anxiety, and treat some types of seizures. Thanks to the 2018 Farm Bill, all hemp-derived products are federally legal across all 50 states, providing they contain 0.3% or less THC, or tetrahydrocannabinol, the other main chemical compound found in the plants. THC levels in the hemp plant differ greatly from the THC levels in the marijuana plant. Because the hemp plant is bred to naturally contain low levels of THC, there is no way that anyone can feel “high” from taking hemp-based CBD products. Conversely, the marijuana plant contains large amounts of THC and will evoke a euphoric “high” sensation from those who use it.

When full-spectrum or broad-spectrum CBD is taken internally, it evokes what is known as the entourage effect. During the entourage effect, the cannabinoids naturally amplify each other’s positive properties while dampening their negative effects. Therefore, the combination of CBD, THC and other cannabinoids have the potential to have a therapeutic and positive effect on seizures and epilepsy. Additionally, every human and animal has an endocannabinoid system, or ECS. The ECS is responsible for regulating critical body functions and processes. For example, the ECS helps to regulate learning, memory, sleep, pain, temperature, immune responses, and much more. Its primary goal is to bring the body back into a state of balance, or homeostasis. Even though the body makes its own endocannabinoids, when someone takes CBD oil, the cannabinoids in the oil enter into the body and assist the endocannabinoids in their job. Therefore, if someone is experiencing seizures and their body’s endocannabinoids are deficient, it makes sense to think that taking CBD oil can help the endocannabinoid system both ease seizure symptoms and potentially reduce the occurrence of seizures altogether.

How CBD Helps with Seizures

As we stated above, the endocannabinoid system plays a huge role in bringing the body back to a state of balance. When CBD interacts with the endocannabinoid system, it can help modify and regulate systems and functions such as pain, sleep, appetite, and more. Scientists believe that the anti-seizure effects of CBD may come from its ability to reduce neuron excitability by working on the GPR55, ENT-1, and TRPV1 receptors, otherwise known as the orphan G protein-coupled receptor-55, equilibrative nucleoside transporter 1, and the Transient receptor potential vanilloid-1. Interestingly, the Food and Drug Administration, or FDA, has approved a prescription CBD medication called Epidiolex to help treat Lennox-Gastaut and Dravet syndromes, two rare forms of epilepsy. The FDA also approved Epidiolex to help treat seizures caused by tuberous sclerosis complex, a genetic disorder. Scientists strongly believe that CBD interacts with the body’s CB1 and CB2 receptors, as well as the three receptors named above, to help alleviate seizures and the symptoms they create.

Other Benefits of CBD

Along with being seen as an antiepileptic, researchers also believe that CBD oil works well against pain, anxiety, and sleep issues. For example, studies prove that CBD oil helps to lower chronic pain by positively impacting endocannabinoid receptor activity, lowering harmful inflammation, and actively working with neurotransmitters and the nervous system in general. While CBD can be effective if used on its own, scientists believe it is more effective when used in combination with THC via full-spectrum CBD products. Additionally, when it comes to anxiety and sleep issues, scientists found that the use of CBD both improves sleep and reduces anxiety by invoking relaxation and soothing chronic pain. Interestingly, a 2014 study found that CBD helped to improve REM sleep behavior disorder, or RBD, which is linked to nightmares and poor sleep.

What is CBD Oil?

CBD oil is a form of CBD created when beneficial cannabinoids, terpenes, and phytonutrients are extracted from hemp or marijuana plants and added to carrier oil. CBD is extracted through many different processes, but the cleanest and most used is the industry preferred CO2 extraction method. Once the extracts are obtained, they are then mixed with a carrier oil, like MCT oil, and natural flavorings to create the final product. CBD oil can come in three different varieties and in a wealth of various strengths and flavors. The three main CBD oil varieties are full-spectrum, broad-spectrum, and CBD isolates. Full-spectrum CBD oils contain all of the components of the hemp plant as well as 0.3% or less THC. Broad-spectrum oils are very much the same as full-spectrum oils, however, they do not contain any THC. Lastly, CBD isolate oils are just what the name implies. With these types of oils, a special process has been used to carefully filter out all of the components of the hemp plant to only leave CBD, or cannabidiol, behind. Typically, full-spectrum and broad-spectrum oils work better against tough health issues as they both invoke the entourage effect and interact best with the ECS.

Does CBD Oil Work for Seizures?

While research on CBD oil and seizures is still ongoing, there is proof that it is effective at alleviating seizures and calming epilepsy. As we discussed above, researchers found that CBD helped to treat Lennox-Gastaut Syndrome, which is most common in two to five percent of pediatric epilepsy cases. Scientists conducted two 14-week clinical trials to determine if Epidiolex would be effective at treating Lennox-Gastaut Syndrome. During the first study, scientists found that half of the participants who took 20mg per kg of Epidiolex a day experienced 44 percent fewer seizures when compared to the placebo group who experienced 22 percent fewer seizures. During the second study, scientists compared the results of 10mg per kg and 20mg per kg of Epidiolex a day with participants and found that those on 20mg per kg of the drug experienced 42 percent fewer seizures, and those on 10mg per kg of the medication experienced 37 percent fewer seizures. The placebo group in the second study experienced 17 percent fewer seizures.

A clinical trial was also held for Dravet Syndrome, which compared the effect of 20mg per kg of daily Epidiolex with a placebo group. The study’s participants ranged from 2 to 18 years of age. Scientists found that the group who took the Epidiolex experienced a 39 percent decrease in seizures when compared to the 17 percent decrease in the placebo group.

Epidiolex was also used in a clinical trial for Tuberous Sclerosis Complex, a rare condition that affects 1 in 6,000 people and that causes benign tumors to grow throughout the body. If these non-cancerous tumors grow in the brain, then they can cause seizures in some people. During the trial, participants were given 25mg per kg and 50mg per kg of Epidiolex per day while others were given a placebo. Out of 148 participants, 48 percent of those on the medication improved versus a 24 percent improvement in the placebo group.

Along with these three conditions, a 2018 study also looked at the effects of CBD on 55 people with epileptic conditions like CDKL5 Deficiency Disorder, Aicardi Syndrome, Doose Syndrome, and Dup15q Syndrome. At the start of the study, participants averaged 59.4 seizures a month. After just 12 weeks, seizures decreased to 22.5 per month. Their seizures continued to improve throughout the entire 48-week duration of the study.

How to Use CBD Oil for Epilepsy

Before using CBD oil on your own, you should always talk with your primary care doctor or medical specialist so that he or she can help you determine if the CBD oil will have any negative interactions with your current prescription medications. You should use your CBD oil exactly as your doctor or medical specialist recommends. It should be noted that CBD has the potential to negatively mix with some seizure medications. When this happens, the medication can become less effective. You should never use CBD as a replacement for your medication unless you have been specifically instructed by your doctor to do so. Some of the prescription drugs that CBD can interact with are:

  • Clobazam
  • Brivaracetam
  • Zonisamide
  • Rufinamide
  • Stiripentol
  • Valproic Acid
  • Topiramate
  • Clobazam

When it comes to taking a dose of CBD oil, you should be patient and consistent. It will take some time for you to feel the effects of CBD oil on your body. Being consistent also helps you to get the most benefits out of the oil. You should strive to take CBD oil at the same time(s) each and every day to ensure that the levels of CBD in your body remain about the same. When you’re using CBD to help with seizures and epilepsy, you should also never abruptly stop taking it, as this may lead to increased seizure activity. Your doctor or medical specialist is always there to help guide you through the process.

CBD Oil Dosage for Epilepsy & Seizures

Since not everyone’s body is the same, CBD oil doses will vary from person to person. It’s also best to consult with your healthcare professional before starting any new CBD regimen, especially where particular medical conditions like neurological disorders are concerned. The best way to find the right dose for your body and your needs is to start low and go slow. Also, higher strengths of CBD oil tend to work best for tougher health conditions. For example, if you have a 600mg bottle of FAB CBD full-spectrum oil, you should begin by taking half a dropper full once a day. This will roughly equal about 10mg of CBD oil a day. Stick with this dose for about one week before checking in with yourself to decide whether or not you need to increase your dose. Now would also be an optimal time to keep a journal detailing your improvements, lingering issues, and how you are feeling while on the CBD oil. If after one week you feel that you need to increase your dose, then feel free to go up to a half dropper full twice a day. This now equals 10mg of CBD twice a day, or 20mg of CBD a day. Stay with the new dose before checking in with yourself again. If you need to increase, then follow the same pattern until you’ve found the best, most effective dose for your body. Keep in mind that you can also increase the strength of the oil if you need to. Additionally, you may have to adjust both the dose and the oil strength over time.

See also  Delta 9 CBD Oil

Dosing Recommendations for Adults

Everyone’s CBD oil dosing will be different. It takes time, patience, and consistency to find the best dose for your body and one that will help alleviate your seizures and calm your epilepsy. In order to find the best dose for your needs, you should follow the detailed method above. If, however, you have been prescribed Epidiolex, you should follow the instructions on the prescription bottle. Typically, the recommended dose of Epidiolex is 2.5mg per kg twice a day. After one week has elapsed, you can increase the dose to 5mg per kg twice a day. Depending on your body’s response and how it tolerates the medication, doctors say the drug can be increased to a maximum amount of 10mg per kg of body weight twice a day.

Where to Buy CBD Oil for Seizures & Epilepsy

Ever since the popularity of CBD has exploded, there’s been an influx of brands in the industry. And while it’s great to have a wealth of brands to choose from, not all brands are created equal. It can be tempting to go with a less-reputable brand that makes cheaper products, but oftentimes these brands cut corners in order to have the lowest prices around. They may use hemp that’s been grown using herbicides and pesticides, or they may use a cheaper extraction method that causes harmful solvents to remain in their final product.

If you’ve been looking to buy CBD oil for your seizures and epilepsy, then it pays to take the time to do your own research into both the product and the brand. If you’re unsure of where to begin, then our list of 15 brands is a great place to start. Once you’ve found some brands that have caught your eye, look deeply into verified customer reviews, industry publications, brand reputation, hemp sources, and even feel free to thoroughly read all third-party lab reports on the brand’s website. It’s important that you know exactly what you are putting into your body as well as the overall reputation of the brand that makes the CBD oil.

These days you can purchase CBD oil from brick and mortar stores and online distributors. Even though brick and mortar stores are easy to get to, you will not be able to thoroughly look into any brand that you’re interested in. Moreover, the staff at the store might not be able to answer your questions in the manner that you’d like them to. If you’re wanting to buy CBD oil, purchasing it online is the best way to go. Not only will you have all the time you need to research the product and the brand, but you’ll also be able to take advantage of coupon codes, special discounts, buying programs, and sales that the brand may be offering.

Final Thoughts on Using CBD for Epilepsy & Seizures

Epilepsy and seizures are extremely difficult to control. Thankfully, with the help of your primary care doctor or medical specialist and the right prescription medication, both issues can be controlled and even alleviated in some cases. Scientific studies are increasingly proving that CBD can be a safe supplemental treatment for seizures and epilepsy. The key to adding CBD oil to your existing medication and supplement routine is to speak with your doctor to first see if you’ll be able to use CBD oil with your prescription(s) and to next discuss what the best oil dose will be for your body and your health needs.

If you’re in the market for a clean and potent CBD oil, the best thing to do is to first take whatever time you need to deeply research both the brand and the product. Don’t be afraid to keep digging until all of your questions are answered to your satisfaction. It’s important to know exactly what you’ll be putting into your body before you begin taking any CBD oil. While there are relatively few side effects of CBD, they are extremely mild at best. Some of the most common side effects linked to CBD oil are drowsiness, dry mouth, nausea, diarrhea, changes in weight, or changes in appetite. If you have been cleared by your doctor to use CBD oil but are concerned about side effects, then don’t hesitate to call him or her to talk more about it and your treatment options.

Best CBD Oil for Seizures & Epilepsy in 2022

According to the Michigan Epilepsy Foundation, 1% of Americans suffer from some form of epilepsy — a recurring neurological disorder known for frequent, often unprovoked seizures.

Epilepsy compromises all aspects of a person’s daily life. The violent tremors caused by a seizure attack can put the individual in grave danger, not to mention that people with epilepsy are also prone to suffer from sleep issues, migraines, anxiety disorders, and depression.

Of all epilepsy forms, up to 40% are drug-resistant, meaning the patient doesn’t react to Antiepileptic Drugs (AEDs). For these patients, AEDs are simply ineffective, or the side effects are too severe to allow for continuous treatment.

As a result, many turn to natural resources to help manage their condition. CBD oil is one promising option whose antiepileptic effects have been thoroughly studied by scientists.

In this article, I’ll cover the potential benefits of CBD oil for epilepsy and seizures — and share the top brands I trust when it comes to manufacturing high-quality CBD oil.

Best CBD Oil Brands for Epilepsy & Seizures

There are lots of different CBD companies trying to make their name in the market with their CBD oil. Some brands provide high-quality products and can back up their claims with third-party lab reports. In contrast, others tend to take advantage of unaware consumers with lots of fancy buzzwords and unrealistic promises.

If you want a clean and potent CBD oil, you need to find a manufacturer that makes organic products with proper quality assurance.

Don’t have time for that? Don’t worry — I did the research for you.

Here are my top 3 brands that make premium CBD oil for different types of consumers.

1. Royal CBD

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.


  • Royal CBD comes from organic hemp grown on American farms
  • The company employs CO2 extraction so their extracts are clean and safe
  • Their CBD oil comes in three different strengths: 250 mg, 500 mg, 1000 mg, and 2500 mg
  • Up to 83.3 mg of CBD per mL
  • Hemp extract is suspended in premium MCT oil
  • Every batch of product has been tested by a third-party laboratory


  • No vapes or vape oils available (yet)
  • The price is on the higher end, although justified
My Thoughts on Royal CBD:

Royal CBD is a premium brand that uses only high-quality ingredients in its product lineup. The company’s product range includes every basic CBD format, from sublingual drops to gummies and capsules.

The oil and capsules are full-spectrum, meaning they also contain other cannabinoids and terpenes from hemp. Gummies, on the other hand, contain 99% pure isolate.

The Royal CBD oil comes in three different potencies: 250 mg, 500 mg, 1000 mg, and 2500 mg. The strongest option gives you 83 mg of CBD/mL. I would recommend this variant for stronger symptoms. Those who need noticeably higher doses of CBD may find the weaker bottles cost-prohibitive.

If you don’t want to measure out the oil each time you need CBD, you may switch to Royal capsules. Each softgel carries 25mg of full-spectrum cannabidiol in an easy-to-swallow form.

All Royal CBD products are sent to third-party laboratories for content analysis — checking the potency of CBD as well as purity levels.

2. Gold Bee (Best Organic)


  • Unique product selection
  • Non-GMO, Colorado-grown hemp
  • Full-spectrum CBD
  • Extracted with CO2
  • Up to 2400 mg of CBD per bottle (80 mg/mL)
  • Sweetened with organic honey
  • Third-party lab tested for potency and purity


  • No high-strength oils
  • Not available in-store
My Thoughts On Gold Bee:

Gold Bee specializes in all-organic CBD products, including full-spectrum CBD oil, high-potency CBD capsules, gummies, and delicious honey sticks. The company’s CBD oil is available in two potency options, 1200 mg, and 2400 mg.

This concentration translates into 40 mg of CBD in each milliliter. The oil has been suspended in premium-grade MCT oil and infused with natural terpenes to enhance the synergy between CBD and other compounds in hemp. There are two flavors available: natural and kiwi. The kiwi flavor is sweetened with organic honey, which only adds to the product’s value.

I’ve been taking the Gold Bee CBD oil for 30 days, using the dosage based on the recommended serving size. At first, I was skeptical because I got used to higher doses in my routine — low doses could hardly calm my nervous system.

To my surprise, 1 mL a day split into two doses was enough to boost my resistance to stress and outside stimuli. After two weeks, I slightly decreased the dosage and was still getting pretty good results. This was the first time a potency lower than 1500 mg lasted more than 1 month for me.

3. CBDPure


  • CBDPure products come from organic hemp grown in Colorado
  • The company uses CO2 extraction
  • All products are tested by 3rd-party laboratories for potency and purity
  • Available in 60 mL bottles
  • 100% Satisfaction Guaranteed program — you can send your order back within 90 days for a full refund


  • CBDPure only sells CBD oil and capsules
  • The oil is slightly less potent than Royal CBD

My Thoughts on CBDPure:

CBDPure was established in 2016 by a group of cannabis advocates from Colorado. The company has a simple mission, which is to make premium-quality CBD oils from organic hemp.

Although CBDPure has a very narrow product range — offering only CBD oil and capsules — they seem to have perfected these products. All extracts from CBDPure are obtained using supercritical CO2 and tested in a certified laboratory for quality assurance.

The oil isn’t as potent as the one offered by Royal CBD, but if you benefit from lower doses, their 60-mL bottles will get you supplied for months to come. Their oils are a good option for people who use CBD for general health care or to ease mild symptoms.

If you’re looking for something potent, try CBDPure capsules — each softgel is infused with 25 mg of full-spectrum CBD for easier dosing and extra convenience.

CBDPure has a Satisfaction Guarantee program, so in case you ended up unsatisfied with your purchase, you can get a full refund if you send the order back within 90 days.

4. CBDistillery


  • CBDistillery uses Colorado-grown hemp
  • Their products are available as full-spectrum or isolate
  • They have an impressive product selection
  • Each batch is sent to a 3rd-party lab for content analysis
  • Very affordable


  • Their hemp isn’t organic

My Thoughts on CBDistillery:

CBDistillery is a company founded in Denver, Colorado. They’ve been offering high-quality CBD oil products for over 5 years now. One of the driving forces behind the brand is to manufacture CBD oil for every budget and promote research and education among consumers all over the country.

CBDistillery has many different forms of CBD, from sublingual tinctures to capsules, gummies, topicals, and vapes. Their CBD oil is available as ‘full-spectrum’ or isolate.

These oils come in two different sizes — 15 mL and 30 mL

The potency of the 15 mL bottle ranges between 150–1,000 mg of CBD. The 30 mL bottle offers from 2,500–5,000 of total CBD.

With such a wide potency range, CBDistillery oils may suit both novice and experienced consumers alike. The only downside to the company’s product range is that they’re not made with organic hemp.

However, this becomes understandable once you consider the price of CBDistillery products. The company may not sell the best CBD oil on the market, but they offer the best CBD products in this price range.

What is CBD Oil?

CBD oil is a cannabis extract with high concentrations of CBD. This product can be sourced from both marijuana and hemp, two members of the cannabis plant family.

It’s worth noting that marijuana-derived CBD oil contains higher levels of THC, the psychoactive cannabinoid responsible for getting users “high.”

CBD oil from hemp has only trace amounts of THC — typically below 0.3% — and thus can’t produce any psychoactive effects.

That’s because CBD is non-psychoactive per se.

CBD oil reportedly has a plethora of health benefits. However, the best-documented evidence thus far comes from epilepsy trials.

Does CBD Oil Work for Seizures?

The earliest studies proving the effectiveness of cannabis compounds in the treatment of convulsions came from animal research from the 1970s. The researchers analyzed the anticonvulsant properties of both THC and CBD oils, concluding that both extracts had substantial effects on mice.

Early experiments reported that the seizure activity might in part, be regulated by the endocannabinoid system — an interconnected network of cannabinoid receptors and neurotransmitters called endocannabinoids.

The Mechanism Behind the Antiepileptic Effects of CBD

The endocannabinoid system works to keep the body in a state of equilibrium, maintaining chemical balance and controlling biological functioning, from appetite to motor control, sensory perception, sleep, and inflammation.

It sends signals to various bodily systems through its chemical messengers called endocannabinoids to do. These molecules bind to the cannabinoid receptors which occur in the brain and throughout the body. By doing so, endocannabinoids help the endocannabinoid system to maintain the healthy functioning of an individual.

Once endocannabinoids have done their work, they get broken down by enzymes to prevent overaccumulation.

As a cannabinoid, CBD is almost identical in its chemical structure to endocannabinoids produced by your body. When you ingest CBD, it’s able to affect cannabinoid receptors on top of acting on several other pathways.

While scientists still don’t know exactly how CBD oil works for seizures, they’ve observed the following interactions which may explain the positive effects:

  1. Endocannabinoids are neuroprotectants, lowering the risk of seizures caused by neurotoxicity. When a person ingests CBD, they introduce more cannabinoids to their system—potentially improving the performance of the endocannabinoid system with their neuroprotective properties.
  2. The endocannabinoid system also modulates neuroexcitation, a process that may trigger seizures. A properly functioning endocannabinoid system, bolstered by additional cannabinoids from CBD oil, may prevent the overexcitation of neurons.
  3. CBD is also an anti-inflammatory agent. Seizures may be triggered, or their frequency may be increased by brain inflammation. By curbing neuroinflammation, CBD may reduce both the severity and frequency of seizure attacks.

Now, let’s elaborate on the scientific findings regarding the antiepileptic properties of CBD oil.

What the Research Says

The majority of specific case studies from the late 1990s, and the early 2000s focused on the effect of THC/CBD solutions on epilepsy. Due to the psychoactive nature of THC, the eyes of modern medicine turned to CBD.

In June 2018, the FDA approved the first CBD-based drug. The oral spray, called Epidiolex, contains 99% pure CBD. It’s used for treatment-resistant forms of childhood epilepsy — such as Lennox-Gastaut syndrome and Dravet syndrome.

Both diseases begin during early childhood and often lead to delayed or poor development of the child’s motor skills, language, intellectual aptitude, and ability to communicate with others.

Before receiving the FDA’s approval, Epidiolex went through three randomized, double-blind, placebo-controlled clinical trials examining 516 patients with either syndrome. When administered along with other medications, Epidiolex successfully reduced the participant’s frequency of seizures compared to the placebo group. Besides, CBD improved other associated symptoms for the participants, such as sleep and anxiety.

Currently, Epidiolex can be officially used to treat these two types of epilepsy. However, recent research suggests that CBD may help relieve other forms of this disease as well.

For instance, a 2015 study analyzing the reports from Epidiolex patients from 11 epilepsy centers across the country showed that the frequency of seizures decreased by 36.5% after a 13-week treatment.

All subjects had severe, childhood-onset forms of epilepsy, including Lennox-Gastaut syndrome and Dravet Syndrome. The researchers started with a dose of 2–5 mg/kg per day and gradually increased it to 25–50 mg/kg per day.

See also  Prime Rx CBD Oil

Can You Develop a Tolerance to CBD Oil for Seizures?

People who have treatment-resistant epilepsy tend to experience a “honeymoon” period upon switching to a new therapy. In other words, they stop feeling the effects of their new treatment after a few months. In late 2018, scientists observed that the same pattern might apply to CBD treatment.

The study examined nearly 100 patients, of which about one-third developed a tolerance to CBD. The tolerance showed up about seven months after they began the therapy. From then on, they had to increase the dose to maintain the effects. When the dose was higher, nearly half of the examined sample experienced their previous response level.

The good news, though, is that for two-thirds of participants, CBD proved effective in the long run.

How to Use CBD Oil for Epilepsy

CBD can take many forms. Epidiolex, the only approved CBD treatment for epilepsy, is an oral solution containing 99% pure CBD.

If you want to use CBD in a more natural form to see how it works for your symptoms, you may try the following formats:

  • Sublingual drops: The most common form of CBD. The drops are administered via a dropper under the tongue, where they get absorbed through special membranes into the bloodstream. Sublingual drops provide the most consistent blood absorption rates according to studies.
  • Capsules: CBD capsules are sold as pills and softgels. You just swallow them like any other pill. They offer a fixed dose of CBD in each serving, which makes dosing easier than sublingual drops, not to mention you can avoid any natural hemp taste.
  • Vape oils: this form of CBD is inhaled through a vaporizer or vape pen. Many people prefer vape oils over other products because they find the act of inhalation relaxing, and they like the flavoring of vape oils. But most importantly, vape oils deliver more CBD to your system than any other consumption method.

CBD Oil Dosage for Epilepsy & Seizures

The dose-finding process will vary between patients. As with every new substance, a conservative approach and slow dosage increase will minimize the chance of severe side effects and leave room for adjusting the dose from the starting point.

For each individual, the optimal CBD dosage will depend on the following:

  • CBD concentration
  • Cannabinoid spectrum
  • Route of administration
  • Weight
  • Age
  • Metabolism
  • Lifestyle choices
  • Medications the patient is already taking

Dr. Karen Keough, Chief Medical Officer at Compassionate Cultivation, created general dosage guidelines for dosing CBD oil to both adults and children who have epilepsy.

Dosing Recommendations for Children

Depending on the severity of symptoms, children may go through low-dose initiation and high-dose initiation.

Low-Dose Initiation instructions:

  • Start with 0.25 mg/lb/day
  • The minimum dose is 10 mg
  • Target dose ranges between 1–5 mg/lb/day. Higher doses are tolerated but at the cost of some mild side effects, such as dry mouth, dry eyes, low blood pressure, sedation, and dizziness.
  • Average dose is 1–3 mg/lb/day
  • Increase the dose every 1–2 weeks by 0.5 mg/lb/day, topping to the nearest 10 mg as long as there are no side effects.

High-Dose Initiation in Children:

  • Start with 0.5mg/lbs/day
  • Target dose ranges between 1–5 mg/lb/day
  • Average dose is 1-3 mg/lb/day
  • Increase the dose every 1–2 weeks by 0.5 mg/lb/day and monitor the effects
  • If side-effects occur, leave more time between dose increases and go up more gradually

Dosing Recommendations for Adults

Considering the factors above, such as body weight and metabolism, adults with epilepsy need more CBD in their regime than children. Use the following guidelines to reach an effective dose:

Low CBD dose in adults:

  • Start with 25 mg twice daily
  • Go up by 25 mg per dose every 1–2 weeks
  • Target dose ranges between 100–300 mg twice a day if no side effects are observed. Clinical trials have utilized doses as high as 1,500 mg of CBD daily, but such high doses might not be necessary to achieve seizure relief in most patients

High CBD dose in adults:

  • Start with 50 mg twice daily
  • Go up every 1–2 weeks by 50 mg/dose
  • Target dose ranges between 200–500 mg twice a day if tolerated. You may stop sooner if seizures are gone to prevent further dosage increase and possible side effects.

Where to Find CBD Oil for Sale for Epilepsy & Seizures

CBD oil is available both in cannabis dispensaries and online retail stores. Dispensaries give you access to a wide range of cannabis products, including CBD oil from hemp. However, these places may not always carry the best products, and the bottles have probably spent some time on the shelves before being sold so that they may lose potency over time due to poor storage.

That’s why I buy my CBD oil online. The majority of CBD stuff is sold this way, so you have more options to choose from. Also, you can verify the reputation of your potential vendor with the help of online research. Read user reviews, check for third-party lab reports, and learn how your company sources its CBD to make sure you’re getting a clean and potent product.

The delivery time for CBD oil is usually 2–3 business days. But in my opinion, it’s worth it to wait a few days more to get a high-quality product for a good price — CBD oil ordered online is usually less expensive than what you see in a dispensary.

Using CBD Oil for Seizures: Will It Help?

Cannabinoids have many proven beneficial effects on health, particularly in the treatment and management of epileptic seizures. Epilepsy is currently the only FDA-approved condition for treatment with CBD — although this approval doesn’t apply to hemp-derived CBD oil.

Still, if you want to try CBD oil for better management of your symptoms, I hope this guide has helped you understand how to use it to get the most out of its benefits. Just remember to start low and slow with the dosage.

But above all, consult with your doctor before purchasing any CBD product — just to make sure it won’t negatively interfere with any medications you’re taking.

Do you know any examples of people who successfully reduced the frequency of their seizures with CBD oil? Share your stories in the comments below!


  1. Filloux, F. M. (2016). Cannabinoids for Pediatric Epilepsy? Up in Smoke or Real Science? Translational Pediatrics, 4(4), 271–282.
  2. Perucca, E. (2017). Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last? Journal of Epilepsy Research, 7(2), 61–76.
  3. Devinsky, O. et al. (2016). Cannabidiol in Patients With Treatment-Resistant Epilepsy: An Open-Label Interventional Trial. The Lancet: Neurology, 15(3), 270–278.
  4. Mannila, J., Jarvinen, T., Jarvinen, K., Jarho, P. (2007). Precipitation Complexation Method Produces Cannabidiol/Beta-Cyclodextrin Inclusion Complex Suitable for Sublingual Administration of Cannabidiol. Journal of Pharmaceutical Sciences, 96(2), 312–9.
  5. Millar, S.A., Stone, N.L., Yates, A.S. & O’Sullivan, S.E. (2018) A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans. Frontiers in Pharmacology, 9, 1365.
Nina Julia

Nina created following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

Cannabidiol (CBD) for Epilepsy Treatment

Epidiolex, a precription form, is approved for some seizures

Heidi Moawad is a neurologist and expert in the field of brain health and neurological disorders. Dr. Moawad regularly writes and edits health and career content for medical books and publications.

Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.

Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles, California.

Cannabidiol (CBD)—a component of the marijuana plant—has gotten a lot of attention for medical use, including the treatment of epilepsy. Epidiolex is the only prescription form of CBD available, and it was approved by the U.S. Food and Drug Administration (FDA) in June 2018 for the treatment of seizures in two hard-to-treat forms epilepsy—Lennox-Gastaut syndrome (LGS) and Dravet syndrome. Epidiolex is approved for adults and children over the age of 2 who have one of these rare disorders.

How It Works

Seizures are caused by erratic electrical activity in the brain that can spread and cause uncontrolled physical movements and/or alterations of consciousness. Most anti-seizure drugs work by slowing down excitatory nerve activity in the brain.

However, LGS and Dravet syndrome may be treated with medications that aren’t commonly used for most types of epilepsy. Additionally, they often require two or more anti-seizure drugs for seizures to be under control.

It is not completely clear why CBD can reduce some types of seizures. It is known to have a range of biochemical effects on nerve cells in the brain, some of which may have an impact on seizures. Medical research on CBD is still in its early stages.


Prescription CBD is specifically recommended for control of seizures in LGS and Dravet syndrome.

LGS is a developmental disorder that begins in early childhood and is characterized by multiple seizure types, as well as physical and cognitive deficits. The seizures of LGS are difficult to control and are managed with a different medication regimen than that which is used for most epilepsy types.

Dravet syndrome is a developmental disorder that begins in early childhood and is associated with multiple seizure types as well as seizures triggered by fevers. People with Dravet syndrome often have behavioral challenges and learning difficulties.

Even with treatment, people with LGS or Dravet syndrome may continue to experience persistent seizures.

However, studies have shown that CBD, when taken with other anti-seizure medications, reduces the frequency and severity of seizures in people who have these disorders.  

A 2019 review of studies on Epidiolex showed a sustained seizure frequency reduction of between 30 and 63 percent.   Additionally, seizures were about half as severe and the postictal (after seizure) state was less severe as well.

What About Other Seizure Types?

Studies using CBD for seizure control are focused on refractory seizures, which are seizures that are not easily controlled with anti-seizure treatments. It’s still too soon to tell whether it will be beneficial and tolerable for people with other seizure types. As such, CBD is not approved for other types of seizures or epilepsy itself at this time.

Cannabidiol is a controversial treatment because it is one of the components of marijuana, a widely known recreational drug. There are strong opinions about the drug, and proponents advocate for its legalization for medical uses, while some advocate for the legalization of recreational use as well.

At this time, cannabidiol has been proven effective for only a few medical conditions. Due to the side effects, it is recommended to be used with caution.

If you have questions regarding whether cannabidiol is an appropriate treatment for you or someone you know, talk to your healthcare provider first. You can use our Doctor Discussion Guide below to help start that conversation about treatment options and more.

Epilepsy Doctor Discussion Guide

Get our printable guide for your next doctor’s appointment to help you ask the right questions.


Epidiolex comes in an oral solution (liquid form), and the recommended dose is initiated based on weight.

It is generally started at a dose of 2.5 mg/kg twice per day and increased weekly. It can be increased up to a dose of 20 mg/kg per day if needed, but increased side effects have been found to occur at the higher dose.

Anti-seizure medications should be taken at the regularly scheduled times without skipping or combining doses.

Sometimes, children and adults who have LGS or Dravet syndrome have some difficulties taking oral medication due to difficulty swallowing, behavioral problems, and/or cognitive issues. It may be a challenge to get your child to take any medication, and you might need to develop strategies to help with this process.

Side Effects

The side effects of CBD that have been reported in the studies when it was added to other antiseizure medications included:

  • Fever
  • Upper respiratory tract infection/rhinitis
  • Drowsiness
  • Generalized fatigue
  • Sleeping difficulties
  • Weakness
  • Decreased appetite
  • Rashes
  • Diarrhea
  • Vomiting (prolonged seizure requiring emergency attention)
  • Fatigue
  • Lethargy

In studies, these were more common in the first two weeks on Epidiolex, after which time they tended to diminish. Additionally, many of the studies on the drug involved at least one other anti-seizure drug as well, so the side effects may not all have been due to Epidiolex.

More severe side effects, which you should contact your healthcare provider about right away, include:

  • Symptoms of liver injury:Jaundice (a yellowish color of the skin and eyes), abdominal pain, vomiting, and dark colored urine
  • Mood changes: Depression, anxiety, and suicidal ideation

Myth Buster

CBD itself does not have abuse potential and does not produce the “high” that is typical of marijuana, so you do not need to worry about your child abusing the drug or becoming addicted to it. However, it is possible that others may misunderstand the effects of the drug, particularly because it is new and because it is derived from the same plant that marijuana is derived from.


There’s still much to be learned about how CBD interacts with other anti-seizure drugs.  

It’s possible that CBD may raise the blood level of certain other anticonvulsants such as Topamax and Onfi (clobazam), and may result in side effects.

When used with other anti-seizure drugs, CBD can cause elevated liver enzymes, which is often a sign of liver injury.

In the aforementioned 2019 review of studies on this drug, however, researchers found that while adding Epidiolex to a treatment regimen may increase certain specific side effects, it may actually decrease the overall amount of side effects participants experienced.

Over-the-Counter CBD Products

A multitude of CBD-containing products are on the market, and some people have chosen to use them for seizure control. This trend is likely to grow, especially since the 2018 Farm Bill made hemp-derived products, including CBD, legal at the federal level.  

However, these products aren’t regulated by the FDA and are largely untested. The FDA has warned that CBD products are often mislabeled or overpromise their supposed benefits.  Dosage and quality are likely to be far less consistent with other CBD products, which may put you at risk for more seizures.

In fact, the FDA has issued warnings to many CBD businesses for illegal practices, including those related to the marketing of their products. In some cases, actual CBD content was negligible or less than 1 percent of what the label claimed.

A 2017 study published in JAMA found that 26 percent of products purchased online contained less CBD than their labels claimed.  


Some other CBD products contained other compounds from the marijuana plant, including tetrahydrocannabinol (THC)—the part that gets you “high.”

A Word From Verywell

Given that CBD is a fairly new therapy for epilepsy, you may experience challenges when it comes to health insurance coverage or availability of the medication. If you do, be sure to involve your healthcare provider, who can provide documentation that can help you get an approval for coverage and may be able to refer you to a source that will fill your prescription.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

US Department of Health and Human Services, U.S. Food and Drug Administration. FDA News release: FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy. June 25, 2018.

Gaston TE, Bebin EM, Cutter GR, Liu Y, Szaflarski JP. Interactions between cannabidiol and commonly used antiepileptic drugs. Epilepsia. 2017;58(9):1586-1592. doi:10.1111/epi.13852

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By Heidi Moawad, MD
Heidi Moawad is a neurologist and expert in the field of brain health and neurological disorders. Dr. Moawad regularly writes and edits health and career content for medical books and publications.

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