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Several studies have investigated the effects of cannabinoids on common dermatological issues. For example, a study in the Journal of Dermatological Science looked at the effects of this family of molecules against keratinocyte hyperproliferation, which is associated with
red, flaky, and scaly skin.
A review published in Trends in Pharmacological Sciences states that the endocannabinoid system of the skin plays a key role in several crucial processes. External cannabinoids share a similar structure to those found in the body, and also target the same receptor sites.
Although transdermal delivery manages to introduce cannabinoids into the bloodstream, topical products offer a different advantage. The skin—much like many other areas of the body—harbours cannabinoid receptors. The endocannabinoid system (ECS) plays a regulatory role in the body and helps many different biological systems maintain homeostasis. The skin is no exception.
Cannabinoids and dermatological issues
Researchers also looked at how cannabinoids affect overproduction of sebum. When this oily substance builds up in the pores, bacteria can form and begin to cause red blemishes. Research published in The Journal of Clinical Investigation tested the effects of CBD on human sebocytes, cells that pump out excess sebum. The researchers found that cannabinoids might help these cells behave normally by acting on TRPV4 and A2A receptors.
Cannabinoids are garnering interest in the world of science. Dozens of these molecules appear in the cannabis plant, and many of them are showing promising results in animal and human studies.
However, transdermal CBD isn’t just a matter of rubbing the cannabinoid into the skin. It requires several adjuvants to make a hydroalcoholic gel capable of penetrating the epidermis. THC also appears to permeate the skin through lipophilic pathways, as evidenced by a 1998 paper that showed transdermal application of delta-8-THC—a more stable form than delta-9-THC—to sustain delivery of the cannabinoid into the bloodstream over 24 hours.
When CBD oil in inhaled, such as through vaporization, the compounds are absorbed through the alveoli in the lungs, which offer a large absorptive surface area. Once through the alveoli, the CBD molecules are immediately transferred into the bloodstream. Compared to ingestion, the inhalation method allows more CBD to be absorbed and offers faster absorption.
When we talk about the absorption of CBD, we’re referring to its transfer from the site of administration to the bloodstream, where it can then be transported throughout the body to interact with or influence cannabinoid receptors CB1 and CB2 , and non-cannabinoid receptors like serotonin receptor 5-HT1A and vanilloid receptor TRPV-1.
The most common route of CBD oil administration is orally, or through the mouth. When CBD is ingested, it is absorbed by the digestive system. From the stomach, the compounds enter the hepatic portal system, where they are carried through the portal vein into the liver. The liver then metabolizes the CBD molecules, in what’s referred to as the “first pass effect.” CYP450 mixed function oxidases enzymes in the liver act upon CBD, reducing the concentration of the compounds before passing on what remains to the bloodstream.
Absorption After Inhalation
Scientists are regularly learning more about cannabidiol (CBD) and how it interacts with receptors throughout the body to elicit balancing and healing effects. Studies suggest that CBD may be able to minimize and even eliminate seizure activity , reduce anxiety and depression , manage pain , fight some cancers , and provide anti-inflammatory and neuroprotective effects that could potentially be beneficial for conditions like Alzheimer’s disease and arthritis . For CBD to have influence over our systems, the natural non-psychoactive compound first need to be absorbed.
Now that you know that the way that CBD is absorbed varies depends on the administration method, you may decide that one method is more ideal than another depending on your needs. However, selecting the method with which you feel most comfortable is important as you’ll more likely be able to be consistent with your servings .
Ingestion, while considered by most to be the easiest administration method, isn’t the most efficient for absorbing high levels of CBD. Studies have found, however, that consuming CBD oil with fatty acids can help bypass first pass metabolism and increase how much CBD is absorbed through ingestion.
If CBD oil is held under the tongue for 60 to 90 seconds before being swallowed, the mucus membranes in the mouth can absorb the compounds. This sublingual method allows CBD to completely bypass the digestive system and liver metabolism, so the compounds can avoid being broken down by enzymes and reach the bloodstream more quickly.